Protein: ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)

Gene: ITPR3
Organism: Homo sapiens
Interactions: 227
UniProt ID: Q14573

Gene Ontology (top 5):
GO:0000822 - inositol hexakisphosphate binding
GO:0005220 - inositol 1,4,5-trisphosphate-gated calcium channel activity
GO:0005509 - calcium ion binding
GO:0005524 - ATP binding
GO:0005640 - nuclear outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

878230

TRPC1
Short transient receptor potential channel 1

3

13

Small-scale

0.834

High

1108489

TRPC3
Short transient receptor potential channel 3

2

13

Small-scale

0.802

High

1128504

TRPC6
Short transient receptor potential channel 6

2

14

Small-scale

0.768

High

1128497

TRPC4
Short transient receptor potential channel 4

2

14

Small-scale

0.767

High

387113

TNNC2
Troponin C, skeletal muscle

1

7

High-throughput

0.691

High

692696

CALL3
Calmodulin-like protein 3

1

4

High-throughput

0.691

High

1128331

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

14

High-throughput

0.691

High

1128397

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

14

High-throughput

0.691

High

1128423

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

1

High-throughput

0.691

High

1128428

RASEF
Ras and EF-hand domain-containing protein

1

2

High-throughput

0.691

High

1128483

CABP2
Calcium-binding protein 2

1

10

High-throughput

0.691

High

1128493

PK2L2
Polycystin-2-like protein 2

1

11

High-throughput

0.691

High

60628

TESP1
Protein TESPA1

3

2

High-throughput

0.667

High

298264

BODG
Gamma-butyrobetaine dioxygenase

3

2

High-throughput

0.667

High

1128500

FBXL2
F-box/LRR-repeat protein 2

3

1

Small-scale

0.664

High

1128485

ANLN
Anillin

3

2

High-throughput

0.656

High

1128481

TRPC7
Short transient receptor potential channel 7

1

13

Small-scale

0.647

High

1128501

TRPC5
Short transient receptor potential channel 5

1

13

Small-scale

0.647

High

343374

SNP29
Synaptosomal-associated protein 29

3

0

High-throughput

0.638

High

170504

RAB7L
Ras-related protein Rab-7L1

2

6

High-throughput

0.628

High

733697

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

2

1

High-throughput

0.628

High

1110339

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

2

11

High-throughput

0.628

High

1128446

LMBL2
Lethal(3)malignant brain tumor-like protein 2

2

1

High-throughput

0.628

High

1125430

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

11

High-throughput

0.618

High

1128415

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.618

High

1125324

FGL2
Fibroleukin

3

4

High-throughput

0.609

High

1128434

FRMD1
FERM domain-containing protein 1

3

2

High-throughput

0.604

High

907013

CCR6
C-C chemokine receptor type 6

2

3

High-throughput

0.601

High

1128452

SGF29
SAGA-associated factor 29

2

2

High-throughput

0.601

High

951148

SC61B
Protein transport protein Sec61 subunit beta

2

2

High-throughput

0.584

High

1128443

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

Small-scale

0.578

High

516517

CALM3
Calmodulin-3

1

4

High-throughput

0.575

High

1119125

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.575

High

1128456

TAFA4
Chemokine-like protein TAFA-4

2

2

High-throughput

0.574

High

1128402

KPCD1
Serine/threonine-protein kinase D1

2

8

High-throughput

0.571

High

1126677

BECN1
Beclin-1

1

1

Small-scale

0.561

High

139130

KRIT1
Krev interaction trapped protein 1

1

1

High-throughput

0.536

High

248704

PEPL
Periplakin

1

9

High-throughput

0.536

High

396112

ESR1
Estrogen receptor

1

6

High-throughput

0.536

High

602788

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

637514

FLNA
Filamin-A

1

1

High-throughput

0.536

High

698656

CALX
Calnexin

1

2

High-throughput

0.536

High

772802

MYH9
Myosin-9

1

5

High-throughput

0.536

High

855322

5HT3A
5-hydroxytryptamine receptor 3A

1

2

High-throughput

0.536

High

866683

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

1052015

CALD1
Caldesmon

1

12

High-throughput

0.536

High

1110242

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

11

High-throughput

0.536

High

1110441

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

11

High-throughput

0.536

High

1120435

SCRB2
Lysosome membrane protein 2

1

1

High-throughput

0.536

High

1128401

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.536

High

1128404

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1128430

SYNPO
Synaptopodin

1

3

High-throughput

0.536

High

1128442

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

1

High-throughput

0.536

High

1128453

MYO19
Unconventional myosin-XIX

1

3

High-throughput

0.536

High

1128494

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

1128495

STIM2
Stromal interaction molecule 2

1

1

High-throughput

0.536

High

1128502

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

11

High-throughput

0.536

High

1128506

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

3

High-throughput

0.536

High

437173

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.515

High

212954

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.513

High

336958

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

High-throughput

0.513

High

446421

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.513

High

598735

ANFB
Natriuretic peptides B

1

0

High-throughput

0.513

High

841732

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

890479

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.513

High

943052

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

958267

ARP2
Actin-related protein 2

1

0

High-throughput

0.513

High

1126288

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1128418

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1128421

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.513

High

1128433

DYLT5
Dynein light chain Tctex-type 5

1

0

High-throughput

0.513

High

1128440

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.513

High

1128469

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.513

High

1128473

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.513

High

1128499

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.513

High

869738

MTR1A
Melatonin receptor type 1A

1

1

High-throughput

0.508

High

880919

MTR1B
Melatonin receptor type 1B

1

1

High-throughput

0.508

High

728235

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.501

High

967726

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

Small-scale

0.501

High

573474

ENPL
Endoplasmin

1

0

Small-scale

0.493

High

973441

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.493

High

1128462

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

822144

PSB10
Proteasome subunit beta type-10

1

1

High-throughput

0.489

High

848623

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

1007473

KRT83
Keratin, type II cuticular Hb3

1

1

High-throughput

0.489

High

126597

RHOD
Rho-related GTP-binding protein RhoD

1

12

High-throughput

0.479

High

157373

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

173916

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

6

High-throughput

0.479

High

272172

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

291332

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

337944

CNEP1
CTD nuclear envelope phosphatase 1

1

3

High-throughput

0.479

High

404056

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

417433

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

418130

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

436866

K1C18
Keratin, type I cytoskeletal 18

1

1

High-throughput

0.479

High

522096

BCL2
Apoptosis regulator Bcl-2

1

5

Small-scale

0.479

High

548334

CP2C9
Cytochrome P450 2C9

1

1

High-throughput

0.479

High

562055

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

581049

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

603980

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

605682

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

9

High-throughput

0.479

High

611121

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

629866

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

634440

LMNB1
Lamin-B1

1

1

High-throughput

0.479

High

768191

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

774356

BASI
Basigin

1

3

High-throughput

0.479

High

801316

HSPA9
Stress-70 protein, mitochondrial

1

1

Small-scale

0.479

High

847530

SSRA
Translocon-associated protein subunit alpha

1

2

High-throughput

0.479

High

867134

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

880548

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

894747

EMD
Emerin

1

2

High-throughput

0.479

High

900812

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.479

High

901239

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.479

High

901810

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.479

High

903907

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.479

High

934611

TERA
Transitional endoplasmic reticulum ATPase

1

5

Small-scale

0.479

High

951673

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

955170

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

962047

RHOA
Transforming protein RhoA

1

12

High-throughput

0.479

High

1015441

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1027001

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.479

High

1035616

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

1041065

CAV1
Caveolin-1

1

3

Small-scale

0.479

High

1111535

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

1128399

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

1128400

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1128403

CAH9
Carbonic anhydrase 9

1

2

High-throughput

0.479

High

1128414

SYNE3
Nesprin-3

1

6

High-throughput

0.479

High

1128420

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.479

High

1128425

MIRO2
Mitochondrial Rho GTPase 2

1

15

High-throughput

0.479

High

1128429

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.479

High

1128432

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1128435

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.479

High

1128436

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.479

High

1128439

RBCC1
RB1-inducible coiled-coil protein 1

1

9

High-throughput

0.479

High

1128445

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1128447

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.479

High

1128451

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

1128454

RN170
E3 ubiquitin-protein ligase RNF170

1

2

High-throughput

0.479

High

1128455

DNJC1
DnaJ homolog subfamily C member 1

1

8

High-throughput

0.479

High

1128457

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

2

High-throughput

0.479

High

1128458

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

1128459

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.479

High

1128461

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

1128463

SGMR1
Sigma non-opioid intracellular receptor 1

1

1

Small-scale

0.479

High

1128466

PCGF1
Polycomb group RING finger protein 1

1

2

High-throughput

0.479

High

1128467

DERL1
Derlin-1

1

2

High-throughput

0.479

High

1128470

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1128472

LNP
Endoplasmic reticulum junction formation protein lunapark

1

3

High-throughput

0.479

High

1128474

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1128475

DJC25
DnaJ homolog subfamily C member 25

1

6

High-throughput

0.479

High

1128476

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.479

High

1128477

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

1128478

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1128479

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

1128482

B2L10
Bcl-2-like protein 10

1

2

Small-scale

0.479

High

1128486

PXMP2
Peroxisomal membrane protein 2

1

2

High-throughput

0.479

High

1128487

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.479

High

1128488

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

1128489

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.479

High

1128490

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.479

High

1128492

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.479

High

1128496

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1128498

SEC63
Translocation protein SEC63 homolog

1

3

High-throughput

0.479

High

1128503

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

247904

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

293688

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

376829

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

390572

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

400836

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

580628

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

588697

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

695457

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

827782

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

851891

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

941903

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

964949

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

979652

H4
Histone H4

1

0

High-throughput

0.458

High

995032

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1033677

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1087109

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

1128406

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1128408

RN213
E3 ubiquitin-protein ligase RNF213

1

0

Small-scale

0.458

High

1128412

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1128417

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

1128419

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1128424

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1128444

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1128450

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1128465

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

1128468

DUS26
Dual specificity protein phosphatase 26

1

0

High-throughput

0.458

High

1128471

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

0

High-throughput

0.458

High

1128480

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1128491

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

170764

CLGN
Calmegin

1

2

High-throughput

0.445

High

351219

MOT3
Monocarboxylate transporter 3

1

3

High-throughput

0.445

High

638195

S1PR1
Sphingosine 1-phosphate receptor 1

1

3

High-throughput

0.445

High

691003

1433T
14-3-3 protein theta

1

2

High-throughput

0.445

High

704009

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.445

High

886053

CXCR3
C-X-C chemokine receptor type 3

1

3

High-throughput

0.445

High

987643

GRB2
Growth factor receptor-bound protein 2

1

2

High-throughput

0.445

High

1007434

S35B1
Solute carrier family 35 member B1

1

3

High-throughput

0.445

High

1103166

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

1128398

MFS10
Major facilitator superfamily domain-containing protein 10

1

2

High-throughput

0.445

High

1128410

MFSD5
Molybdate-anion transporter

1

2

High-throughput

0.445

High

1128411

NPAL3
NIPA-like protein 3

1

2

High-throughput

0.445

High

1128427

S35F3
Solute carrier family 35 member F3

1

2

High-throughput

0.445

High

1128437

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

4

High-throughput

0.445

High

1128438

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

6

High-throughput

0.445

High

1128441

S35F5
Solute carrier family 35 member F5

1

5

High-throughput

0.445

High

1128460

S1PR3
Sphingosine 1-phosphate receptor 3

1

3

High-throughput

0.445

High

1128484

S35C2
Solute carrier family 35 member C2

1

2

High-throughput

0.445

High

1128505

S27A5
Long-chain fatty acid transport protein 5

1

2

High-throughput

0.445

High

630801

RAB4A
Ras-related protein Rab-4A

1

3

High-throughput

0.437

High

976271

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.437

High

1128409

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.437

High

1128422

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.437

High

1128449

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

1128416

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.426

High

1128431

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1128405

S35F1
Solute carrier family 35 member F1

1

5

High-throughput

0.407

High

1128407

ANR22
Ankyrin repeat domain-containing protein 22

1

1

High-throughput

0.407

High

1128426

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

298910

DNJB5
DnaJ homolog subfamily B member 5

1

0

High-throughput

0.249

Low

1128413

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

1128464

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low

1128448

FUCT1
GDP-fucose transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025