HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.916

The method score is based on:

Property Details
Experiments 25402006, 24658140, 7678409, 16273093, unassigned2173
Identification Methods two hybrid, protein complementation assay, affinity chromatography technology, unspecified method, ubiquitin reconstruction, protein array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 14 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024