HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: GAB3 (Q8WWW8)
GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)
Gene: GAB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18235045
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 586
+	Hs
		166023 ABL1_HUMAN (1-1130): 0: 984: 100.00		SYNJ2_HUMAN (138-572): 8.44e-34: 139: 9.11
+	Hs
		337335 ABL1_HUMAN (1-1130): 0: 984: 100.00		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		523086 SRC_HUMAN (13-510): 0: 547: 38.58		GAB3_HUMAN (1-586): 1.2e-108: 339: 100.00
+	Hs
		412280 FYN_HUMAN (18-510): 0: 543: 38.64		GAB3_HUMAN (1-586): 1.2e-108: 339: 100.00
+	Hs
		523213 SRC_HUMAN (13-510): 0: 547: 38.58		GAB2_HUMAN (2-585): 1.27e-75: 255: 31.29
+	Hs
		411861 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		PKHA5_HUMAN (4-580): 9.83e-67: 237: 12.52
+	Hs
		522965 SRC_HUMAN (13-510): 0: 547: 38.58		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Mm
		403466 SRC_MOUSE (13-510): 0: 545: 38.19		GAB1_MOUSE (1-585): 1.34e-51: 190: 27.44
+	Hs
		433345 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		433388 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		PKHA7_HUMAN (5-478): 7.4e-49: 185: 11.91
+	Hs
		411709 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		411764 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		PKHA7_HUMAN (5-478): 7.4e-49: 185: 11.91
+	Hs
		442825 HCK_HUMAN (9-508): 5.18e-175: 526: 38.79		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		166024 FYN_HUMAN (18-510): 0: 543: 38.64		SYNJ2_HUMAN (138-572): 8.44e-34: 139: 9.11
+	Hs
		411897 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		PKHA6_HUMAN (4-458): 2.39e-36: 147: 13.21
+	Hs
		297808 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		K0754_HUMAN (100-573): 5.03e-30: 128: 11.04
+	Hs
		522749 SRC_HUMAN (13-510): 0: 547: 38.58		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		411582 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		203198 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		SYNJ1_HUMAN (110-572): 1.24e-12: 73.3: 9.79
+	Hs
		411772 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		MPRIP_HUMAN (8-301): 3.32e-10: 65.2: 13.38