Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: UCHL1 (P09936)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.82 | 0.60 | 0.705 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 32042339, 32494592, 20029029, unassigned2173 |
| Identification Methods | affinity chromatography technology, pull down, enzymatic study, protein complementation assay, ubiquitin reconstruction, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0031625 - ubiquitin protein ligase binding GO:0071466 - cellular response to xenobiotic stimulus |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
