Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.91 | 0.60 | 0.742 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24797263, 25402006, 24658140, 9535896, 14517306, 35384245, unassigned2173 |
| Identification Methods | affinity chromatography technology, two hybrid, protein complementation assay, pull down, enzymatic study, proximity labelling technology, ubiquitin reconstruction |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0019903 - protein phosphatase binding and 4 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
