Protein: CLD5
Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF)

Gene: CLD5, CLDN5
Organism: Homo sapiens
Interactions: 44
UniProt ID: O00501

Gene Ontology (top 5):
GO:0003151 - outflow tract morphogenesis
GO:0005198 - structural molecule activity
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
GO:0005923 - bicellular tight junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

138557

PMP22
Peripheral myelin protein 22

2

5

High-throughput

0.783

High

138565

BTNL8
Butyrophilin-like protein 8

2

2

High-throughput

0.783

High

138544

CLD3
Claudin-3

1

6

Small-scale

0.618

High

138546

LAT
Linker for activation of T-cells family member 1

2

2

High-throughput

0.606

High

138547

TSN2
Tetraspanin-2

2

6

High-throughput

0.606

High

138548

VAMP5
Vesicle-associated membrane protein 5

2

2

High-throughput

0.606

High

138553

AQP1
Aquaporin-1

2

4

High-throughput

0.606

High

138554

MIP
Lens fiber major intrinsic protein

2

4

High-throughput

0.606

High

138559

PLP2
Proteolipid protein 2

2

1

High-throughput

0.606

High

138564

TM128
Transmembrane protein 128

2

1

High-throughput

0.606

High

138567

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

2

High-throughput

0.606

High

138569

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

1

High-throughput

0.606

High

138573

PLPR2
Phospholipid phosphatase-related protein type 2

2

1

High-throughput

0.606

High

138575

SMIM3
Small integral membrane protein 3

2

2

High-throughput

0.606

High

138578

RPRM
Protein reprimo

2

2

High-throughput

0.606

High

138579

TM140
Transmembrane protein 140

2

1

High-throughput

0.606

High

138584

ERG28
Ergosterol biosynthetic protein 28 homolog

2

1

High-throughput

0.606

High

138586

CORIN
Atrial natriuretic peptide-converting enzyme

2

1

High-throughput

0.606

High

138549

GLPA
Glycophorin-A

2

0

High-throughput

0.580

High

138550

TRFE
Serotransferrin

2

0

High-throughput

0.580

High

138556

EFNA5
Ephrin-A5

2

0

High-throughput

0.580

High

138563

SGCG
Gamma-sarcoglycan

2

0

High-throughput

0.580

High

138566

TM182
Transmembrane protein 182

2

0

High-throughput

0.580

High

138577

TM222
Transmembrane protein 222

2

0

High-throughput

0.580

High

138582

CC167
Coiled-coil domain-containing protein 167

2

0

High-throughput

0.580

High

138585

YIPF1
Protein YIPF1

2

0

High-throughput

0.580

High

49761

CLRN2
Clarin-2

2

1

High-throughput

0.553

High

138561

CXCL9
C-X-C motif chemokine 9

2

2

High-throughput

0.553

High

138568

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

2

3

High-throughput

0.553

High

138572

S35B4
Nucleotide sugar transporter SLC35B4

2

3

High-throughput

0.553

High

138583

TM14C
Transmembrane protein 14C

2

1

High-throughput

0.553

High

138560

ZO1
Tight junction protein 1

1

20

Small-scale

0.501

High

138576

FXYD6
FXYD domain-containing ion transport regulator 6

1

1

High-throughput

0.481

High

138545

KLF4
Krueppel-like factor 4

1

1

Small-scale

0.479

High

138562

ECHP
Peroxisomal bifunctional enzyme

1

2

High-throughput

0.470

High

138580

TBA8
Tubulin alpha-8 chain

1

1

High-throughput

0.439

High

138552

GATA1
Erythroid transcription factor

1

1

Small-scale

0.437

High

138571

GATA6
Transcription factor GATA-6

1

1

Small-scale

0.437

High

138551

PSPC
Surfactant protein C

2

0

High-throughput

0.316

High

138555

CTRL
Chymotrypsin-like protease CTRL-1

2

0

High-throughput

0.316

High

138570

TM190
Transmembrane protein 190

2

0

High-throughput

0.316

High

138574

CNPY3
Protein canopy homolog 3

2

0

High-throughput

0.316

High

138581

TECR
Very-long-chain enoyl-CoA reductase

2

0

High-throughput

0.316

High

138558

SP3
Transcription factor Sp3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025