HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: IL5RA (Q01344)
Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)
Gene: IL5RA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10823900
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016020 - membrane GO:0043235 - receptor complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 420
+	Hs
		338437 EGFR_HUMAN (1-1210): 0: 1241: 100.00		I13R2_HUMAN (21-373): 7.49e-61: 203: 24.59
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (13-408): 2.12e-22: 102: 11.18
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (13-274): 3.43e-18: 89.5: 12.03
+	Hs
		383808 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		I13R2_HUMAN (21-373): 7.49e-61: 203: 24.59
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (3-242): 3.39e-11: 67.6: 12.00
+	Hs
		338057 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IL6RB_HUMAN (12-340): 1.37e-10: 65.3: 9.86
+	Hs
		383712 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EPHA4_HUMAN (29-239): 3.11e-16: 83: 10.39
+	Hs
		383632 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EPHB2_HUMAN (25-238): 4.58e-14: 76.4: 11.92
+	Hs
		383631 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EPHA3_HUMAN (29-256): 1.36e-12: 71.8: 13.25
+	Hs
		383711 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		EPHB1_HUMAN (23-237): 2.97e-11: 67.6: 9.79
+	Hs
		383660 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IL6RB_HUMAN (12-340): 1.37e-10: 65.3: 9.86
+	Hs
		601828 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		IL6RB_HUMAN (12-340): 1.37e-10: 65.3: 9.86
+	Hs
		434120 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PTPRF_HUMAN (13-274): 3.43e-18: 89.5: 12.03
+	Mm
		872618 EPHB2_MOUSE (640-1067): 7.47e-121: 400: 28.09		EPHA4_MOUSE (29-239): 4.17e-17: 85.7: 10.39
+	Mm
		975145 EPHA4_MOUSE (660-1016): 1.38e-120: 399: 31.52		EPHA4_MOUSE (29-239): 4.17e-17: 85.7: 10.39
+	Hs
		665567 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		EPHB2_HUMAN (25-238): 4.58e-14: 76.4: 11.92
+	Mm
		872617 EPHB2_MOUSE (640-1067): 7.47e-121: 400: 28.09		EPHB2_MOUSE (25-238): 4.47e-14: 76.4: 11.92
+	Hs
		665568 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		EPHB2_HUMAN (25-238): 4.58e-14: 76.4: 11.92
+	Hs
		665385 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		EPHA3_HUMAN (29-256): 1.36e-12: 71.8: 13.25