HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CKAP4 (Q07065)
Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63)
Gene: CKAP4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	25754235, 15657067
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0016020 - membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 602
+	Hs
		338037 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MYH9_HUMAN (299-602): 6.56e-11: 67.9: 16.78
+	Hs
		601904 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		CKAP4_HUMAN (1-602): 2e-38: 151: 100.00
+	Hs
		434179 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		CKAP4_HUMAN (1-602): 2e-38: 151: 100.00
+	Hs
		305100 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		RIMB1_HUMAN (21-511): 1.49e-43: 169: 14.76
+	Hs
		411364 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		CKAP4_HUMAN (1-602): 2e-38: 151: 100.00
+	Hs
		1189813 EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80		MYH14_HUMAN (127-597): 5.01e-26: 116: 13.49
+	Hs
		665375 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		MYH9_HUMAN (299-602): 6.56e-11: 67.9: 16.78
+	Mm
		222845 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH10_MOUSE (29-602): 1.93e-20: 98.3: 9.45
+	Mm
		222875 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH9_MOUSE (5-481): 5.09e-16: 84.1: 12.68
+	Hs
		983639 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		RBCC1_HUMAN (159-601): 1.73e-09: 63.3: 17.47
+	Mm
		222882 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MY18A_MOUSE (239-594): 7.08e-09: 61.1: 12.78
+	Hs
		537734 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		CKAP4_HUMAN (1-602): 2e-38: 151: 100.00
+	Hs
		435621 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		CKAP4_HUMAN (1-602): 2e-38: 151: 100.00