HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTPRK (Q15262)
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)
Gene: PTPRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase, Recep_L_domain~fn3
Common GO terms GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0009986 - cell surface
GO:0016020 - membrane
GO:0019901 - protein kinase binding
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1210
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024