HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SH319 (Q5HYK7)
SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP)
Gene: SH3D19

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 790
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (417-786): 3.11e-27: 121: 18.20
+	Hs
		337883 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (498-718): 2.72e-24: 103: 20.27
+	Hs
		208970 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (498-718): 1.8e-24: 104: 20.27
+	Hs
		339199 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CD2AP_HUMAN (300-607): 3.02e-17: 88.2: 10.87
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (680-790): 7.11e-16: 84.4: 24.78
+	Hs
		275158 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRAP2_HUMAN (305-554): 1.65e-16: 83.6: 15.20
+	Hs
		298945 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRBS2_HUMAN (612-787): 2.26e-15: 82.6: 22.53
+	Hs
		338817 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Hs
		338633 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH3R1_HUMAN (244-550): 1.54e-09: 63.7: 11.61
+	Hs
		338935 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRBS1_HUMAN (672-788): 2.98e-09: 62.8: 33.07
+	Hs
		557701 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Hs
		209056 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Hs
		924589 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		383587 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Hs
		208972 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Hs
		275197 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRAP2_HUMAN (305-554): 1.65e-16: 83.6: 15.20
+	Hs
		275161 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRAP2_HUMAN (305-554): 1.65e-16: 83.6: 15.20