HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	12177062, 33643898, 12218189, 21635887, 11894095, 35384245, 15456872, 12734385, 16849543, 12771190
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 665
+	Hs
		339199 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		337883 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (2-158): 6.97e-33: 128: 19.91
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		964571 EGFR_MOUSE (1-1210): 0: 1258: 90.35		ARHG7_MOUSE (228-354): 2.05e-13: 75.9: 21.88
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (84-158): 6.98e-13: 74: 27.63
+	Hs
		275158 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		208970 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		338419 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG7_HUMAN (228-354): 4.83e-14: 77.8: 20.31
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		338823 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q96D37_HUMAN (84-158): 4.48e-13: 74.7: 28.95
+	Hs
		338633 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH3R1_HUMAN (241-599): 5.37e-12: 71.2: 13.28
+	Hs
		298945 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRBS2_HUMAN (3-155): 4.65e-11: 68.2: 30.86
+	Hs
		338526 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31
+	Hs
		275197 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		209056 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		548711 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95