HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RN125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Gene: RNF125

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 232
+	Hs
		242796 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TRI13_HUMAN (28-228): 2.21e-34: 128: 15.17
+	Mm
		250610 ERBB2_MOUSE (5-1200): 0: 1116: 48.46		LNX1_MOUSE (18-142): 6.57e-24: 101: 20.77
+	Hs
		1071011 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		RNF41_HUMAN (37-120): 3.22e-10: 60.9: 24.18
+	Hs
		601996 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		RNF41_HUMAN (37-120): 3.22e-10: 60.9: 24.18
+	Hs
		1072615 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		KCMF1_HUMAN (55-217): 7.13e-28: 110: 19.16
+	Hs
		242800 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		TRI13_HUMAN (28-228): 2.21e-34: 128: 15.17
+	Hs
		1072546 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		LNX2_HUMAN (1-138): 3.55e-26: 108: 22.82
+	Hs
		872678 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17
+	Hs
		665633 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17
+	Hs
		1072558 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17
+	Hs
		411494 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		RNF41_HUMAN (37-120): 3.22e-10: 60.9: 24.18
+	Hs
		796648 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		796559 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89
+	Mm
		815741 KSYK_MOUSE (718-961): 3.5e-53: 199: 42.04		TRI31_MOUSE (22-231): 1.51e-31: 122: 14.60
+	Mm
		815731 KSYK_MOUSE (718-961): 3.5e-53: 199: 42.04		TRAF3_MOUSE (5-175): 5.08e-29: 115: 18.18
+	Hs
		796680 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39
+	Mm
		815726 KSYK_MOUSE (718-961): 3.5e-53: 199: 42.04		TRAF6_MOUSE (6-174): 3.2e-27: 110: 22.67
+	Hs
		796483 ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59		RNF41_HUMAN (37-120): 3.22e-10: 60.9: 24.18
+	Hs
		242801 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		TRI13_HUMAN (28-228): 2.21e-34: 128: 15.17
+	Hs
		435761 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		RNF41_HUMAN (37-120): 3.22e-10: 60.9: 24.18