HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTN18 (Q99952)
Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)
Gene: PTPN18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	25402006, 24658140, unassigned2173
Identification Methods	two hybrid, protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 460
+	Mm
		728828 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN12_MOUSE (4-421): 2.75e-134: 407: 35.55
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (5-315): 1.47e-127: 409: 31.66
+	Hs
		338312 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN12_HUMAN (4-413): 2.43e-135: 409: 35.73
+	Hs
		337987 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN6_HUMAN (5-325): 7.54e-131: 392: 32.95
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (8-299): 2.29e-117: 371: 37.16
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (4-294): 1.55e-107: 351: 32.44
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (4-307): 3.85e-109: 342: 32.79
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (3-294): 1.09e-103: 341: 31.33
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (5-307): 4.4e-101: 318: 30.77
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (4-362): 2.82e-80: 272: 24.31
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (22-294): 8.09e-63: 222: 27.76
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (9-295): 9.98e-62: 219: 26.10
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (4-316): 2.2e-57: 206: 24.77
+	Mm
		719299 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN11_MOUSE (51-297): 6.26e-45: 167: 38.70
+	Hs
		338510 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN20_HUMAN (50-292): 2.11e-49: 175: 41.13
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (50-313): 1.3e-44: 169: 38.04
+	Hs
		338317 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN11_HUMAN (51-297): 6.26e-45: 167: 38.70
+	Hs
		338350 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN13_HUMAN (51-288): 3.78e-43: 165: 39.10
+	Hs
		337903 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN1_HUMAN (54-290): 2.48e-44: 162: 37.14
+	Hs
		338025 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN7_HUMAN (54-301): 1.67e-42: 155: 37.45