HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RAI14 (Q9P0K7)
Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)
Gene: RAI14

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~GF_recep_IV, Ank_2~Recep_L_domain
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 980
+	Hs
		338353 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANK3_HUMAN (24-405): 2.11e-47: 187: 18.74
+	Hs
		338310 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NOTC2_HUMAN (10-123): 1.42e-14: 81.1: 22.61
+	Hs
		60297 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		POTEF_HUMAN (16-586): 4.55e-65: 240: 18.67
+	Hs
		601939 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		POTEE_HUMAN (16-586): 7.23e-65: 239: 18.85
+	Hs
		339124 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KDIS_HUMAN (160-403): 1.98e-12: 73.9: 16.39
+	Hs
		602024 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		KDIS_HUMAN (160-403): 1.98e-12: 73.9: 16.39
+	Hs
		434233 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		MIB1_HUMAN (1-552): 5.8e-59: 221: 18.56
+	Hs
		434183 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		ANK3_HUMAN (24-405): 2.11e-47: 187: 18.74
+	Hs
		665280 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		MIB1_HUMAN (1-552): 5.8e-59: 221: 18.56
+	Hs
		665591 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ANK3_HUMAN (24-405): 2.11e-47: 187: 18.74
+	Hs
		665656 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		UACA_HUMAN (411-974): 2.3e-39: 161: 24.63
+	Hs
		411283 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		POTEJ_HUMAN (2-549): 7.92e-34: 142: 15.04
+	Hs
		434176 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		NOTC2_HUMAN (10-123): 1.42e-14: 81.1: 22.61
+	Mm
		222882 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MY18A_MOUSE (351-942): 1.33e-76: 277: 20.16
+	Hs
		872634 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		NOTC2_HUMAN (10-123): 1.42e-14: 81.1: 22.61
+	Hs
		665584 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		NOTC2_HUMAN (10-123): 1.42e-14: 81.1: 22.61
+	Hs
		980379 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		NOTC2_HUMAN (10-123): 1.42e-14: 81.1: 22.61
+	Hs
		665360 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		KDIS_HUMAN (160-403): 1.98e-12: 73.9: 16.39
+	Mm
		222880 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		RAI14_MOUSE (1-980): 9.26e-70: 253: 82.16
+	Hs
		665439 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		KDIS_HUMAN (160-403): 1.98e-12: 73.9: 16.39