HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: DOK5 (Q9P104)
Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)
Gene: DOK5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 306
+	Hs
		338574 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK6_HUMAN (1-306): 2.09e-126: 365: 70.13
+	Hs
		338739 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK4_HUMAN (1-298): 9.29e-119: 346: 60.33
+	Mm
		250953 EGFR_MOUSE (1-1210): 0: 1258: 90.35		DOK2_MOUSE (6-292): 1.38e-75: 238: 20.85
+	Hs
		235032 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK2_HUMAN (6-268): 2.63e-76: 240: 22.42
+	Hs
		383858 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOK6_HUMAN (1-306): 2.09e-126: 365: 70.13
+	Hs
		338891 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK1_HUMAN (6-264): 5.18e-72: 231: 22.59
+	Hs
		339187 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS2_HUMAN (8-304): 5.4e-63: 217: 17.01
+	Hs
		383894 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOK4_HUMAN (1-298): 9.29e-119: 346: 60.33
+	Hs
		338618 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOK3_HUMAN (9-267): 4.7e-65: 213: 19.73
+	Hs
		338036 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS1_HUMAN (2-304): 2.19e-61: 212: 19.34
+	Hs
		151678 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS4_HUMAN (6-234): 5.15e-54: 191: 19.47
+	Hs
		338745 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRS2_HUMAN (129-263): 9.3e-29: 116: 21.92
+	Hs
		383949 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DOK1_HUMAN (6-264): 5.18e-72: 231: 22.59
+	Hs
		383652 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IRS1_HUMAN (2-304): 2.19e-61: 212: 19.34
+	Hs
		151685 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IRS4_HUMAN (6-234): 5.15e-54: 191: 19.47
+	Hs
		207289 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		FRS3_HUMAN (126-303): 7.07e-42: 152: 20.79
+	Hs
		434219 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DOK6_HUMAN (1-306): 2.09e-126: 365: 70.13
+	Hs
		434248 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DOK4_HUMAN (1-298): 9.29e-119: 346: 60.33
+	Hs
		235038 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DOK2_HUMAN (6-268): 2.63e-76: 240: 22.42
+	Hs
		434249 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		FRS2_HUMAN (129-263): 9.3e-29: 116: 21.92