Protein: SUMO3
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)

Gene: SUMO3
Organism: Homo sapiens
Interactions: 121
UniProt ID: P55854

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016605 - PML body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

939176

UBC9
SUMO-conjugating enzyme UBC9

7

19

Small-scale

0.965

High

939232

SENP2
Sentrin-specific protease 2

5

20

Small-scale

0.938

High

939234

SENP1
Sentrin-specific protease 1

3

20

Small-scale

0.862

High

297778

PIAS2
E3 SUMO-protein ligase PIAS2

3

20

Small-scale

0.841

High

297530

PIAS1
E3 SUMO-protein ligase PIAS1

2

20

Small-scale

0.800

High

339147

TYDP2
Tyrosyl-DNA phosphodiesterase 2

2

2

Small-scale

0.800

High

939197

USPL1
SUMO-specific isopeptidase USPL1

3

2

Small-scale

0.793

High

939172

SUMO2
Small ubiquitin-related modifier 2

2

12

High-throughput

0.789

High

939235

SAE1
SUMO-activating enzyme subunit 1

2

10

High-throughput

0.776

High

939186

TDG
G/T mismatch-specific thymine DNA glycosylase

1

2

Small-scale

0.680

High

939199

ZCH12
Zinc finger CCHC domain-containing protein 12

3

2

High-throughput

0.667

High

939223

SENP5
Sentrin-specific protease 5

1

20

Small-scale

0.647

High

939243

PIAS3
E3 SUMO-protein ligase PIAS3

1

20

Small-scale

0.647

High

713982

PML
Protein PML

3

10

Small-scale

0.633

High

939239

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

2

8

Small-scale

0.619

High

939169

SUMO3
Small ubiquitin-related modifier 3

1

12

High-throughput

0.618

High

939171

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.618

High

939183

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.618

High

939236

SAE2
SUMO-activating enzyme subunit 2

1

10

Small-scale

0.618

High

659194

SP100
Nuclear autoantigen Sp-100

2

12

Small-scale

0.611

High

176291

ZBT39
Zinc finger and BTB domain-containing protein 39

2

2

High-throughput

0.606

High

939204

KAISO
Transcriptional regulator Kaiso

2

3

High-throughput

0.606

High

939224

ZN496
Zinc finger protein 496

2

2

High-throughput

0.606

High

939211

PIAS4
E3 SUMO-protein ligase PIAS4

1

20

High-throughput

0.590

High

939225

ATX2
Ataxin-2

2

4

Small-scale

0.588

High

939178

RNF4
E3 ubiquitin-protein ligase RNF4

2

10

Small-scale

0.584

High

302444

RNF8
E3 ubiquitin-protein ligase RNF8

1

10

Small-scale

0.561

High

939209

SLX4
Structure-specific endonuclease subunit SLX4

1

8

Small-scale

0.561

High

474582

VIME
Vimentin

1

6

High-throughput

0.541

High

685141

PAX6
Paired box protein Pax-6

1

3

High-throughput

0.541

High

766075

PCGF2
Polycomb group RING finger protein 2

1

4

High-throughput

0.541

High

939187

MORC3
MORC family CW-type zinc finger protein 3

1

1

High-throughput

0.541

High

939206

HIPK1
Homeodomain-interacting protein kinase 1

1

10

High-throughput

0.541

High

939220

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.541

High

939237

ZMYM2
Zinc finger MYM-type protein 2

1

7

High-throughput

0.541

High

939240

ARIP4
Helicase ARIP4

1

20

High-throughput

0.541

High

939241

ZN451
E3 SUMO-protein ligase ZNF451

1

2

High-throughput

0.541

High

939205

CARM1
Histone-arginine methyltransferase CARM1

1

4

High-throughput

0.536

High

939184

CAF1A
Chromatin assembly factor 1 subunit A

1

5

Small-scale

0.527

High

939181

CAV1
Caveolin-1

2

1

High-throughput

0.521

High

939196

SYDE2
Rho GTPase-activating protein SYDE2

2

2

High-throughput

0.521

High

472554

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.518

High

843425

HD
Huntingtin

1

2

High-throughput

0.515

High

927199

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

187323

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

405427

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.508

High

627946

ANXA7
Annexin A7

1

6

High-throughput

0.508

High

939182

UBE3A
Ubiquitin-protein ligase E3A

1

3

High-throughput

0.508

High

939190

MAPK3
MAP kinase-activated protein kinase 3

1

4

High-throughput

0.508

High

861959

YAP1
Transcriptional coactivator YAP1

1

4

Small-scale

0.501

High

939200

RN111
E3 ubiquitin-protein ligase Arkadia

1

5

Small-scale

0.501

High

939226

WWTR1
WW domain-containing transcription regulator protein 1

1

3

Small-scale

0.501

High

939227

HIPK2
Homeodomain-interacting protein kinase 2

1

8

Small-scale

0.501

High

939230

EGLN3
Prolyl hydroxylase EGLN3

1

3

Small-scale

0.501

High

939238

DAXX
Death domain-associated protein 6

1

5

Small-scale

0.501

High

212184

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

4

Small-scale

0.500

High

773719

ACTN2
Alpha-actinin-2

1

7

High-throughput

0.489

High

261779

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.486

High

808000

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

939189

SMN
Survival motor neuron protein

1

0

High-throughput

0.486

High

939208

HOMEZ
Homeobox and leucine zipper protein Homez

1

8

High-throughput

0.481

High

129690

CBX4
E3 SUMO-protein ligase CBX4

1

5

Small-scale

0.479

High

172624

XPO1
Exportin-1

1

6

High-throughput

0.479

High

259694

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

413495

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

446807

NPM
Nucleophosmin

1

2

Small-scale

0.479

High

507735

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.479

High

543567

ERR1
Steroid hormone receptor ERR1

1

10

Small-scale

0.479

High

849313

RANG
Ran-specific GTPase-activating protein

1

7

High-throughput

0.479

High

878844

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

919840

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.479

High

933932

NR1H2
Oxysterols receptor LXR-beta

1

9

Small-scale

0.479

High

939170

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.479

High

939173

ERR3
Estrogen-related receptor gamma

1

10

Small-scale

0.479

High

939174

H4
Histone H4

1

3

High-throughput

0.479

High

939175

RAN
GTP-binding nuclear protein Ran

1

4

High-throughput

0.479

High

939177

H31
Histone H3.1

1

5

High-throughput

0.479

High

939179

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

939191

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

Small-scale

0.479

High

939198

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.479

High

939202

ARC
Activity-regulated cytoskeleton-associated protein

1

3

Small-scale

0.479

High

939210

RN168
E3 ubiquitin-protein ligase RNF168

1

3

Small-scale

0.479

High

939219

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

939229

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

389806

TTHY
Transthyretin

1

2

High-throughput

0.464

High

939231

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

400551

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

939194

MIDN
Midnolin

1

0

High-throughput

0.458

High

841033

HELZ
Probable helicase with zinc finger domain

1

3

Small-scale

0.445

High

854612

RAGP1
Ran GTPase-activating protein 1

1

5

Small-scale

0.445

High

889697

CLK3
Dual specificity protein kinase CLK3

1

3

Small-scale

0.445

High

934336

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.445

High

939180

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

1

Small-scale

0.445

High

939185

RLF
Zinc finger protein Rlf

1

1

Small-scale

0.445

High

939188

NEDD8
Ubiquitin-like protein NEDD8

1

4

Small-scale

0.445

High

939192

H2B2E
Histone H2B type 2-E

1

3

Small-scale

0.445

High

939193

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

1

Small-scale

0.445

High

939195

BEND3
BEN domain-containing protein 3

1

1

Small-scale

0.445

High

939201

DHX30
ATP-dependent RNA helicase DHX30

1

4

Small-scale

0.445

High

939212

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

7

Small-scale

0.445

High

939214

ARI1B
AT-rich interactive domain-containing protein 1B

1

4

Small-scale

0.445

High

939218

DDB2
DNA damage-binding protein 2

1

1

Small-scale

0.445

High

939222

RBM33
RNA-binding protein 33

1

4

Small-scale

0.445

High

939233

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

11

Small-scale

0.445

High

939242

NCOR2
Nuclear receptor corepressor 2

1

6

Small-scale

0.445

High

648808

KCNA5
Potassium voltage-gated channel subfamily A member 5

1

5

Small-scale

0.437

High

939216

PAR3L
Partitioning defective 3 homolog B

1

1

High-throughput

0.437

High

137126

MEIS1
Homeobox protein Meis1

1

0

Small-scale

0.426

High

939203

NUFP2
FMR1-interacting protein NUFIP2

1

0

Small-scale

0.426

High

939213

FA98A
Protein FAM98A

1

0

Small-scale

0.426

High

939221

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

Small-scale

0.426

High

426067

PPB1
Alkaline phosphatase, placental type

1

1

Small-scale

0.407

High

690214

STOM
Stomatin

1

2

Small-scale

0.407

High

939207

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

1

Small-scale

0.407

High

939217

ATX2L
Ataxin-2-like protein

1

5

Small-scale

0.407

High

939228

ZN106
Zinc finger protein 106

1

1

Small-scale

0.407

High

61843

F221A
Protein FAM221A

2

0

High-throughput

0.316

High

925500

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.249

Low

939215

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

720453

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025