HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	24797263, 34591612, 35384245
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005925 - focal adhesion GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 999
+	Hs
		338778 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320783 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		338020 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		384047 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		320789 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		383646 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		338019 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS71L_HUMAN (682-814): 9.92e-31: 131: 15.04
+	Hs
		338520 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q59EJ3_HUMAN (682-813): 1.16e-30: 131: 16.67
+	Hs
		337839 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		338516 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q53GZ6_HUMAN (682-815): 2.34e-30: 130: 16.42
+	Hs
		337827 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS71A_HUMAN (682-813): 3.35e-30: 129: 16.67
+	Hs
		338182 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HSP72_HUMAN (682-814): 8.57e-30: 128: 16.54
+	Hs
		338514 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q53FC7_HUMAN (682-813): 3.1e-27: 120: 20.46
+	Hs
		434320 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		665690 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		383840 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q53FC7_HUMAN (682-813): 3.1e-27: 120: 20.46
+	Hs
		503428 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		1072565 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320795 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		503499 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42