Protein: TRAF5
TNF receptor-associated factor 5 (RING finger protein 84)

Gene: TRAF5
Organism: Homo sapiens
Interactions: 100
UniProt ID: O00463

Gene Ontology (top 5):
GO:0005164 - tumor necrosis factor receptor binding
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

136736

TRAF6
TNF receptor-associated factor 6

9

18

Small-scale

0.976

High

136640

TRAF5
TNF receptor-associated factor 5

6

17

Small-scale

0.951

High

136687

TRAF3
TNF receptor-associated factor 3

6

18

Small-scale

0.944

High

136686

TRAF2
TNF receptor-associated factor 2

4

17

Small-scale

0.907

High

136662

TNR5
Tumor necrosis factor receptor superfamily member 5

11

20

Small-scale

0.754

High

136703

MAVS
Mitochondrial antiviral-signaling protein

6

19

Small-scale

0.731

High

136688

NMI
N-myc-interactor

5

3

High-throughput

0.726

High

136706

HOME1
Homer protein homolog 1

5

19

High-throughput

0.717

High

136666

TNR3
Tumor necrosis factor receptor superfamily member 3

5

20

Small-scale

0.711

High

136641

SDCB1
Syntenin-1

4

17

High-throughput

0.707

High

136737

TNR11
Tumor necrosis factor receptor superfamily member 11A

4

20

Small-scale

0.703

High

136714

TNR14
Tumor necrosis factor receptor superfamily member 14

3

20

Small-scale

0.677

High

136671

SPB9
Serpin B9

3

8

High-throughput

0.675

High

136674

SEC13
Protein SEC13 homolog

3

10

High-throughput

0.675

High

136698

CC184
Coiled-coil domain-containing protein 184

3

1

High-throughput

0.675

High

136731

THAP1
THAP domain-containing protein 1

3

9

High-throughput

0.675

High

136664

TNR8
Tumor necrosis factor receptor superfamily member 8

3

20

Small-scale

0.667

High

136713

TANK
TRAF family member-associated NF-kappa-B activator

3

9

Small-scale

0.664

High

136643

TR13B
Tumor necrosis factor receptor superfamily member 13B

2

8

Small-scale

0.644

High

136720

M3K5
Mitogen-activated protein kinase kinase kinase 5

3

20

Small-scale

0.640

High

136730

FBX28
F-box only protein 28

4

3

High-throughput

0.638

High

136697

CCD40
Coiled-coil domain-containing protein 40

2

7

High-throughput

0.628

High

136647

CIKS
E3 ubiquitin ligase TRAF3IP2

2

12

Small-scale

0.611

High

136649

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

136650

PIAS2
E3 SUMO-protein ligase PIAS2

2

11

High-throughput

0.606

High

136654

DRC4
Dynein regulatory complex subunit 4

2

1

High-throughput

0.606

High

136661

PSA1
Proteasome subunit alpha type-1

2

10

High-throughput

0.606

High

136677

YPEL5
Protein yippee-like 5

2

1

High-throughput

0.606

High

136678

SUMO1
Small ubiquitin-related modifier 1

2

12

High-throughput

0.606

High

136679

RNF4
E3 ubiquitin-protein ligase RNF4

2

15

High-throughput

0.606

High

136694

CDC37
Hsp90 co-chaperone Cdc37

2

4

High-throughput

0.606

High

136699

ODFP2
Outer dense fiber protein 2

2

9

High-throughput

0.606

High

136709

ZN655
Zinc finger protein 655

2

16

High-throughput

0.606

High

136711

LNX1
E3 ubiquitin-protein ligase LNX

2

20

High-throughput

0.606

High

136717

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

4

High-throughput

0.606

High

136723

THAP7
THAP domain-containing protein 7

2

9

High-throughput

0.606

High

136728

PICK1
PRKCA-binding protein

2

2

High-throughput

0.606

High

136715

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

20

Small-scale

0.595

High

136738

NUMBL
Numb-like protein

2

10

Small-scale

0.586

High

136689

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

20

Small-scale

0.584

High

136668

TNR4
Tumor necrosis factor receptor superfamily member 4

2

20

Small-scale

0.579

High

136673

RD23A
UV excision repair protein RAD23 homolog A

1

20

High-throughput

0.573

High

136693

ENOX2
Ecto-NOX disulfide-thiol exchanger 2

1

2

High-throughput

0.573

High

136701

ZFAN6
AN1-type zinc finger protein 6

1

2

High-throughput

0.573

High

136733

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.561

High

136684

SRSF1
Serine/arginine-rich splicing factor 1

1

20

Small-scale

0.554

High

136676

LMO4
LIM domain transcription factor LMO4

2

14

High-throughput

0.553

High

136708

FAM9A
Protein FAM9A

2

4

High-throughput

0.553

High

136718

CIB3
Calcium and integrin-binding family member 3

2

3

High-throughput

0.553

High

136655

CPNS1
Calpain small subunit 1

1

2

High-throughput

0.541

High

136659

TRI27
Zinc finger protein RFP

1

19

High-throughput

0.541

High

136681

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

High-throughput

0.541

High

136702

RN111
E3 ubiquitin-protein ligase Arkadia

1

7

High-throughput

0.541

High

136705

DGKH
Diacylglycerol kinase eta

1

4

High-throughput

0.541

High

136725

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

20

High-throughput

0.541

High

136648

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.536

High

136669

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

1

1

Small-scale

0.536

High

136682

TNR17
Tumor necrosis factor receptor superfamily member 17

1

4

Small-scale

0.536

High

136727

GORS2
Golgi reassembly-stacking protein 2

1

6

High-throughput

0.523

High

136645

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

Small-scale

0.515

High

136683

TNR9
Tumor necrosis factor receptor superfamily member 9

1

20

Small-scale

0.515

High

136691

ZMY11
Zinc finger MYND domain-containing protein 11

1

20

Small-scale

0.515

High

136658

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

136665

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.515

High

136704

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

11

High-throughput

0.515

High

136685

GOGA2
Golgin subfamily A member 2

1

16

High-throughput

0.512

High

136652

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

Small-scale

0.501

High

136657

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.501

High

136735

COG5
Conserved oligomeric Golgi complex subunit 5

1

0

High-throughput

0.493

High

136642

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.493

High

136670

MEOX2
Homeobox protein MOX-2

1

20

High-throughput

0.481

High

136712

PIBF1
Progesterone-induced-blocking factor 1

1

7

High-throughput

0.481

High

136721

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

Small-scale

0.481

High

136644

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.479

High

136646

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.479

High

136651

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

12

High-throughput

0.479

High

136653

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

3

Small-scale

0.479

High

136656

TNR16
Tumor necrosis factor receptor superfamily member 16

1

20

Small-scale

0.479

High

136660

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

20

Small-scale

0.479

High

136663

CD27
CD27 antigen

1

20

Small-scale

0.479

High

136667

IL6RB
Interleukin-6 receptor subunit beta

1

6

Small-scale

0.479

High

136672

RORG
Nuclear receptor ROR-gamma

1

13

Small-scale

0.479

High

136675

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

Small-scale

0.479

High

136690

CUL3
Cullin-3

1

20

High-throughput

0.479

High

136692

ELAV1
ELAV-like protein 1

1

17

Small-scale

0.479

High

136695

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

7

Small-scale

0.479

High

136707

TCAM1
TIR domain-containing adapter molecule 1

1

13

Small-scale

0.479

High

136710

NF2IP
NFATC2-interacting protein

1

4

Small-scale

0.479

High

136716

DHX58
ATP-dependent RNA helicase DHX58

1

20

Small-scale

0.479

High

136719

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

20

Small-scale

0.479

High

136722

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

136724

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

20

Small-scale

0.479

High

136726

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

20

Small-scale

0.479

High

136729

TNR19
Tumor necrosis factor receptor superfamily member 19

1

10

Small-scale

0.479

High

136734

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

20

Small-scale

0.479

High

136696

Q4G0R1
PIBF1 protein

1

7

High-throughput

0.470

High

136700

Q6FHY5
MEOX2 protein

1

20

High-throughput

0.470

High

136680

COG7
Conserved oligomeric Golgi complex subunit 7

2

0

High-throughput

0.337

High

136732

COMD3
COMM domain-containing protein 3

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025