HitPredict

Interactor 1: CPSF4 (O95639)
Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)
Gene: CPSF4

Interactor 2: CPSF1 (Q10570)
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)
Gene: CPSF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	29395067, 24981860, 28514442, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~zf-CCCH, CPSF_A~zf-CCCH_3
Common GO terms	GO:0005654 - nucleoplasm GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex GO:0006397 - mRNA processing
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 269 Hs			1 1443
+	Hs
		1083388 ZC3HE_HUMAN (61-186): 1.77e-21: 95.4: 22.37		CPSF1_HUMAN (1-1443): 0: 1602: 100.00
+	At
		72341 CPSF_ARATH (5-144): 1.62e-30: 121: 35.17		CPSF1_ARATH (2-1442): 0: 1072: 29.98
+	Sp
		267967 YTH1_SCHPO (65-173): 2.57e-32: 118: 54.96		CFT1_SCHPO (1-1442): 0: 1040: 25.13
+	Sc
		1053587 YTH1_YEAST (1-185): 1.21e-38: 136: 38.34		CFT1_YEAST (3-678): 9.86e-115: 395: 18.62