HitPredict

Interactor 1: THRB (P00734)
Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
Gene: F2

Interactor 2: IPSP (P05154)
Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5)
Gene: SERPINA5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	18362344
Identification Methods	x-ray crystallography
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0008201 - heparin binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 622 Hs			1 406
+	Mm
		581130 THRB_MOUSE (1-621): 0: 594: 80.90		SPA3C_MOUSE (6-406): 9.21e-169: 480: 42.86
+	Hs
		341138 THRB_HUMAN (1-622): 0: 611: 100.00		SPB6_HUMAN (40-406): 4.31e-140: 406: 32.28
+	Hs
		341117 THRB_HUMAN (1-622): 0: 611: 100.00		ANT3_HUMAN (24-406): 1.03e-138: 405: 28.46
+	Hs
		341125 THRB_HUMAN (1-622): 0: 611: 100.00		PAI1_HUMAN (5-406): 4.35e-131: 384: 27.30
+	Hs
		397654 HGFA_HUMAN (75-618): 1.92e-100: 321: 24.87		IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00
+	Hs
		371455 FA11_HUMAN (89-619): 3.95e-100: 319: 23.16		IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00
+	Hs
		371463 KLKB1_HUMAN (88-620): 2.03e-96: 310: 23.35		IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00
+	Hs
		341527 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00
+	Mm
		430527 Q9Z1R9_MOUSE (356-620): 3.63e-87: 273: 33.59		A1AT1_MOUSE (25-406): 2.77e-154: 443: 40.67
+	Hs
		1304624 ST14_HUMAN (234-617): 5.31e-100: 325: 27.64		NEUS_HUMAN (31-406): 8.93e-129: 378: 26.74
+	Hs
		341525 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		PAI2_HUMAN (41-406): 4.96e-146: 422: 28.09
+	Hs
		341545 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		SPB6_HUMAN (40-406): 4.31e-140: 406: 32.28
+	Hs
		428671 TRY1_HUMAN (357-621): 3.34e-88: 275: 32.08		SPB8_HUMAN (41-406): 4.69e-141: 408: 32.63
+	Hs
		341526 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		PAI1_HUMAN (5-406): 4.35e-131: 384: 27.30
+	Hs
		341558 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		NEUS_HUMAN (31-406): 8.93e-129: 378: 26.74
+	Hs
		375826 PROC_HUMAN (22-166): 8.79e-31: 127: 27.33		IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00
+	Hs
		344172 CTRL_HUMAN (363-617): 5.8e-36: 137: 36.72		A1AT_HUMAN (6-406): 9.76e-161: 460: 43.07
+	Hs
		341268 FA9_HUMAN (10-193): 2.91e-32: 131: 26.74		ANT3_HUMAN (24-406): 1.03e-138: 405: 28.46
+	Hs
		341478 UROK_HUMAN (53-262): 5.01e-19: 91.8: 17.76		PAI2_HUMAN (41-406): 4.96e-146: 422: 28.09
+	Hs
		341564 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		ZPI_HUMAN (47-406): 1.54e-55: 191: 32.33