Protein: E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)

Gene: E2AK3, EIF2AK3
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q9NZJ5

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001503 - ossification
GO:0001525 - angiogenesis
GO:0002063 - chondrocyte development
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1348233

SCN3B
Sodium channel regulatory subunit beta-3

2

1

High-throughput

0.811

High

502621

BIP
Endoplasmic reticulum chaperone BiP

6

20

Small-scale

0.724

High

1028116

DNJC3
DnaJ homolog subfamily C member 3

1

20

Small-scale

0.724

High

391220

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

4

2

High-throughput

0.699

High

781469

BCL6
B-cell lymphoma 6 protein

1

5

Small-scale

0.691

High

851709

NEK4
Serine/threonine-protein kinase Nek4

1

19

High-throughput

0.691

High

952885

FOXK1
Forkhead box protein K1

1

12

High-throughput

0.691

High

964273

FOXK2
Forkhead box protein K2

1

17

High-throughput

0.691

High

1223769

DND1
Dead end protein homolog 1

1

15

High-throughput

0.691

High

1162495

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

3

1

High-throughput

0.667

High

538428

ENPL
Endoplasmin

1

20

Small-scale

0.665

High

1349203

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

17

Small-scale

0.665

High

398770

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

15

Small-scale

0.647

High

1349220

TBL2
Transducin beta-like protein 2

3

13

Small-scale

0.640

High

1328582

GL8D2
Glycosyltransferase 8 domain-containing protein 2

3

0

High-throughput

0.638

High

884431

TMPS3
Transmembrane protease serine 3

2

6

High-throughput

0.628

High

1166907

DLK2
Protein delta homolog 2

2

6

High-throughput

0.628

High

1216200

TF2LY
Homeobox protein TGIF2LY

2

2

High-throughput

0.628

High

1349214

PCDGG
Protocadherin gamma-B4

2

11

High-throughput

0.628

High

989263

FMOD
Fibromodulin

1

5

High-throughput

0.618

High

120678

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

201832

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

9

Small-scale

0.618

High

432311

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

436542

RHOC
Rho-related GTP-binding protein RhoC

1

17

High-throughput

0.618

High

545662

RAC2
Ras-related C3 botulinum toxin substrate 2

1

16

High-throughput

0.618

High

591699

RAB3B
Ras-related protein Rab-3B

1

8

High-throughput

0.618

High

592541

RAB5A
Ras-related protein Rab-5A

1

10

High-throughput

0.618

High

682044

AKT1
RAC-alpha serine/threonine-protein kinase

1

16

Small-scale

0.618

High

845300

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.618

High

845776

RAB9A
Ras-related protein Rab-9A

1

13

High-throughput

0.618

High

852652

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

886069

RHBL3
Rhomboid-related protein 3

1

2

Small-scale

0.618

High

892634

RAC3
Ras-related C3 botulinum toxin substrate 3

1

17

High-throughput

0.618

High

894520

CDC42
Cell division control protein 42 homolog

1

18

High-throughput

0.618

High

900982

RHOA
Transforming protein RhoA

1

18

High-throughput

0.618

High

951408

RHOG
Rho-related GTP-binding protein RhoG

1

16

High-throughput

0.618

High

1053230

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

20

High-throughput

0.618

High

1070424

RAB35
Ras-related protein Rab-35

1

8

High-throughput

0.618

High

1296097

DNJC1
DnaJ homolog subfamily C member 1

1

16

High-throughput

0.618

High

1328874

DJC25
DnaJ homolog subfamily C member 25

1

10

High-throughput

0.618

High

1349204

BFAR
Bifunctional apoptosis regulator

1

10

High-throughput

0.618

High

1349211

SEC63
Translocation protein SEC63 homolog

1

8

High-throughput

0.618

High

1349217

DJC16
DnaJ homolog subfamily C member 16

1

20

High-throughput

0.618

High

390582

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

3

High-throughput

0.611

High

354780

DRA
HLA class II histocompatibility antigen, DR alpha chain

3

9

High-throughput

0.609

High

533173

HLAE
HLA class I histocompatibility antigen, alpha chain E

3

6

High-throughput

0.609

High

1349210

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

3

5

High-throughput

0.609

High

514491

PSPC
Surfactant protein C

2

0

High-throughput

0.602

High

1161914

NCEH1
Neutral cholesterol ester hydrolase 1

2

0

High-throughput

0.602

High

1349208

P2RX2
P2X purinoceptor 2

2

0

High-throughput

0.602

High

1316098

EIF2A
Eukaryotic translation initiation factor 2A

2

9

Small-scale

0.584

High

989657

ACHD
Acetylcholine receptor subunit delta

2

5

High-throughput

0.574

High

1236762

PCD20
Protocadherin-20

2

15

High-throughput

0.574

High

1291447

ASIC4
Acid-sensing ion channel 4

2

6

High-throughput

0.574

High

1349215

PCDA4
Protocadherin alpha-4

2

10

High-throughput

0.574

High

1349216

PCDAC
Protocadherin alpha-12

2

10

High-throughput

0.574

High

1192651

VTCN1
V-set domain-containing T-cell activation inhibitor 1

1

5

Small-scale

0.553

High

354999

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

2

7

High-throughput

0.552

High

354901

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

9

High-throughput

0.536

High

570900

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

5

High-throughput

0.536

High

677178

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

5

High-throughput

0.536

High

763119

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.536

High

901955

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

2

High-throughput

0.536

High

1035097

TUSC3
Tumor suppressor candidate 3

1

3

High-throughput

0.536

High

1103676

HFE
Hereditary hemochromatosis protein

1

7

High-throughput

0.536

High

1127438

NHLC3
NHL repeat-containing protein 3

1

3

High-throughput

0.536

High

1253692

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.536

High

1289641

ARSG
Arylsulfatase G

1

2

High-throughput

0.536

High

1343937

ITM2C
Integral membrane protein 2C

1

5

High-throughput

0.536

High

1349205

VAPA
Vesicle-associated membrane protein-associated protein A

1

7

High-throughput

0.536

High

1349212

TSN16
Tetraspanin-16

1

3

High-throughput

0.536

High

1349218

TMED7
Transmembrane emp24 domain-containing protein 7

1

8

High-throughput

0.536

High

1349221

PCDBB
Protocadherin beta-11

1

9

High-throughput

0.536

High

1081256

NF2L2
Nuclear factor erythroid 2-related factor 2

1

12

Small-scale

0.527

High

473166

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

1063653

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

786765

GRIA3
Glutamate receptor 3

1

11

High-throughput

0.489

High

942317

ASIC1
Acid-sensing ion channel 1

1

6

High-throughput

0.489

High

1060420

KI2S3
Killer cell immunoglobulin-like receptor 2DS3

1

3

High-throughput

0.489

High

1134311

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

3

High-throughput

0.489

High

1245435

OR6T1
Olfactory receptor 6T1

1

1

High-throughput

0.489

High

1349222

PCDB1
Protocadherin beta-1

1

8

High-throughput

0.489

High

1349223

PCDG4
Protocadherin gamma-A4

1

11

High-throughput

0.489

High

1349224

ST14
Suppressor of tumorigenicity 14 protein

1

7

High-throughput

0.489

High

48542

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

164019

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

10

High-throughput

0.479

High

178821

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

274018

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

488412

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

6

High-throughput

0.479

High

550996

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.479

High

567303

CXA1
Gap junction alpha-1 protein

1

8

High-throughput

0.479

High

573946

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

10

High-throughput

0.479

High

579384

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

17

Small-scale

0.479

High

632428

TNR6
Tumor necrosis factor receptor superfamily member 6

1

8

Small-scale

0.479

High

654853

CALX
Calnexin

1

6

High-throughput

0.479

High

786168

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

9

High-throughput

0.479

High

795313

SSRA
Translocon-associated protein subunit alpha

1

2

High-throughput

0.479

High

825577

LMAN1
Protein ERGIC-53

1

5

High-throughput

0.479

High

839192

EMD
Emerin

1

4

High-throughput

0.479

High

890473

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

909242

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.479

High

961862

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.479

High

990718

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.479

High

1017827

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

1019672

ILF2
Interleukin enhancer-binding factor 2

1

13

Small-scale

0.479

High

1019982

ILF3
Interleukin enhancer-binding factor 3

1

20

Small-scale

0.479

High

1023826

TRAF1
TNF receptor-associated factor 1

1

9

Small-scale

0.479

High

1040285

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

1087625

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.479

High

1168717

SYNE3
Nesprin-3

1

20

High-throughput

0.479

High

1236543

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.479

High

1240341

DHB11
Estradiol 17-beta-dehydrogenase 11

1

5

High-throughput

0.479

High

1256061

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.479

High

1272651

CSN5
COP9 signalosome complex subunit 5

1

10

Small-scale

0.479

High

1284124

LRC59
Leucine-rich repeat-containing protein 59

1

5

High-throughput

0.479

High

1303190

RMD3
Regulator of microtubule dynamics protein 3

1

2

High-throughput

0.479

High

1303606

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

1311432

ESYT1
Extended synaptotagmin-1

1

3

High-throughput

0.479

High

1313084

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1329307

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

5

High-throughput

0.479

High

1333601

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

1345076

TMPS4
Transmembrane protease serine 4

1

5

High-throughput

0.479

High

1349209

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

1349213

CLC4E
C-type lectin domain family 4 member E

1

6

High-throughput

0.479

High

1349219

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

1

High-throughput

0.479

High

847699

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

1156735

TECT3
Tectonic-3

1

0

High-throughput

0.458

High

1300799

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1301241

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

1319277

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1344332

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1344451

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1346187

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1348598

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1349206

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1349207

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

206079

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.437

High

1198204

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.437

High

1230405

CXD3
Gap junction delta-3 protein

1

8

High-throughput

0.437

High

1263920

CLC4D
C-type lectin domain family 4 member D

1

7

High-throughput

0.437

High

1283964

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

1217201

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.426

High

354228

IGHD
Immunoglobulin heavy constant delta

1

2

High-throughput

0.407

High

206542

B4GA1
Beta-1,4-glucuronyltransferase 1

2

0

High-throughput

0.328

High

351661

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.279

Low

771164

TPOR
Thrombopoietin receptor

1

0

High-throughput

0.279

Low

1245383

OR2M7
Olfactory receptor 2M7

1

0

High-throughput

0.279

Low

1283173

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024