HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: FHR4 (Q92496)
Complement factor H-related protein 4 (FHR-4)
Gene: CFHR4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	10622723, 20042240, 32034129
Identification Methods	pull down, enzyme linked immunosorbent assay, solid phase assay, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006956 - complement activation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1663 Hs			1 578
+	Hs
		344710 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR5_HUMAN (1-578): 3.89e-122: 373: 34.68
+	Hs
		344663 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR1_HUMAN (271-577): 6.14e-67: 222: 39.74
+	Hs
		344662 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR3_HUMAN (1-323): 5.15e-65: 217: 48.32
+	Hs
		344636 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR1_HUMAN (3-456): 1.13e-46: 178: 18.42
+	Hs
		344638 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR2_HUMAN (328-578): 2.83e-29: 125: 22.64
+	Hs
		344619 CO3_HUMAN (1-1663): 0: 2219: 100.00		F13B_HUMAN (332-578): 2.63e-29: 124: 23.83
+	Hs
		341566 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAB_HUMAN (2-207): 3.1e-18: 90.7: 22.47
+	Hs
		344632 CO3_HUMAN (1-1663): 0: 2219: 100.00		MCP_HUMAN (394-578): 7.05e-17: 84.9: 16.92
+	Hs
		119680 CO3_HUMAN (1-1663): 0: 2219: 100.00		MASP2_HUMAN (23-170): 5.41e-10: 64.1: 16.05
+	Hs
		344624 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAH_HUMAN (452-578): 5.78e-09: 61.4: 17.42
+	Mm
		344735 CO3_MOUSE (1-1663): 0: 2139: 76.77		CFAH_MOUSE (452-578): 5.65e-10: 64.5: 18.46
+	Hs
		469908 CO4B_HUMAN (16-1661): 0: 1625: 28.37		FHR4_HUMAN (1-578): 7.11e-165: 483: 100.00
+	Hs
		469878 CO4A_HUMAN (16-1661): 0: 1624: 28.20		FHR4_HUMAN (1-578): 7.11e-165: 483: 100.00
+	Hs
		344753 CO5_HUMAN (10-1661): 0: 1664: 27.73		CO6_HUMAN (331-574): 3.12e-21: 100: 15.29
+	Hs
		416130 CO4B_HUMAN (16-1661): 0: 1625: 28.37		CO2_HUMAN (27-207): 1.2e-21: 101: 18.88
+	Hs
		416129 CO4A_HUMAN (16-1661): 0: 1624: 28.20		CO2_HUMAN (27-207): 1.2e-21: 101: 18.88
+	Hs
		469899 CO4B_HUMAN (16-1661): 0: 1625: 28.37		MCP_HUMAN (394-578): 7.05e-17: 84.9: 16.92
+	Hs
		119684 CO4B_HUMAN (16-1661): 0: 1625: 28.37		MASP2_HUMAN (23-170): 5.41e-10: 64.1: 16.05
+	Hs
		119683 CO4A_HUMAN (16-1661): 0: 1624: 28.20		MASP2_HUMAN (23-170): 5.41e-10: 64.1: 16.05
+	Hs
		344406 A2MG_HUMAN (19-1498): 0: 1369: 23.02		F13B_HUMAN (332-578): 2.63e-29: 124: 23.83