Protein: Q6AXH7
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356)

Gene: Q6AXH7, Ezh2
Organism: Mus musculus
Interactions: 128
UniProt ID: Q6AXH7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0032259 - methylation
GO:0048511 - rhythmic process
GO:0140951 - histone H3K27 trimethyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1231049

SUZ12
Polycomb protein Suz12

1

11

High-throughput

0.691

High

312601

O88568
Heterogeneous nuclear ribonucleoprotein U

1

11

High-throughput

0.575

High

1017361

H33
Histone H3.3

1

20

High-throughput

0.575

High

1222066

RBBP4
Histone-binding protein RBBP4

1

20

High-throughput

0.575

High

1222092

RBBP7
Histone-binding protein RBBP7

1

20

High-throughput

0.575

High

1231066

EED
Polycomb protein EED

1

20

High-throughput

0.575

High

237059

COPB2
Coatomer subunit beta'

1

9

High-throughput

0.514

High

1188037

Q3TAU7
Coatomer subunit alpha

1

11

High-throughput

0.514

High

1000016

HDAC2
Histone deacetylase 2

1

20

High-throughput

0.484

High

1204082

Q5DTP7
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.484

High

204285

PHB2
Prohibitin-2

1

3

High-throughput

0.445

High

312612

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

13

High-throughput

0.445

High

462125

HS90A
Heat shock protein HSP 90-alpha

1

10

High-throughput

0.445

High

518683

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.445

High

575069

LMNB1
Lamin-B1

1

16

High-throughput

0.445

High

723735

CTND1
Catenin delta-1

1

11

High-throughput

0.445

High

776010

PRDX1
Peroxiredoxin-1

1

6

High-throughput

0.445

High

778134

RL12
Large ribosomal subunit protein uL11

1

1

High-throughput

0.445

High

881007

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

12

High-throughput

0.445

High

887486

MCM4
DNA replication licensing factor MCM4

1

9

High-throughput

0.445

High

912298

KPYM
Pyruvate kinase PKM

1

2

High-throughput

0.445

High

945608

EF1D
Elongation factor 1-delta

1

3

High-throughput

0.445

High

945640

RU2A
U2 small nuclear ribonucleoprotein A'

1

3

High-throughput

0.445

High

949818

PCBP1
Poly(rC)-binding protein 1

1

9

High-throughput

0.445

High

966023

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

9

High-throughput

0.445

High

974884

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

High-throughput

0.445

High

981762

RAN
GTP-binding nuclear protein Ran

1

9

High-throughput

0.445

High

989256

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.445

High

1000301

ELAV1
ELAV-like protein 1

1

4

High-throughput

0.445

High

1021197

PKP1
Plakophilin-1

1

12

High-throughput

0.445

High

1023470

TBB5
Tubulin beta-5 chain

1

5

High-throughput

0.445

High

1189937

Q3U6P5
RRM domain-containing protein

1

12

High-throughput

0.445

High

1221127

SIN3A
Paired amphipathic helix protein Sin3a

1

4

High-throughput

0.445

High

1221168

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

1

High-throughput

0.445

High

1224051

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.445

High

1225143

RALY
RNA-binding protein Raly

1

8

High-throughput

0.445

High

1231043

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

9

High-throughput

0.445

High

1231046

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.445

High

1231048

DSG1B
Desmoglein-1-beta

1

2

High-throughput

0.445

High

1231055

FLNA
Filamin-A

1

9

High-throughput

0.445

High

1231056

TOX4
TOX high mobility group box family member 4

1

20

High-throughput

0.445

High

1231057

MYEF2
Myelin expression factor 2

1

8

High-throughput

0.445

High

1231058

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.445

High

1231059

MATR3
Matrin-3

1

5

High-throughput

0.445

High

1231060

SF3A1
Splicing factor 3A subunit 1

1

14

High-throughput

0.445

High

1231064

PRP6
Pre-mRNA-processing factor 6

1

12

High-throughput

0.445

High

1231067

TADBP
TAR DNA-binding protein 43

1

11

High-throughput

0.445

High

1231069

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.445

High

1231072

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

7

High-throughput

0.445

High

1231076

GTF2I
General transcription factor II-I

1

2

High-throughput

0.445

High

1231082

MAGD1
Melanoma-associated antigen D1

1

8

High-throughput

0.445

High

1231083

RUVB2
RuvB-like 2

1

8

High-throughput

0.445

High

1231086

ILF3
Interleukin enhancer-binding factor 3

1

8

High-throughput

0.445

High

1231087

AEBP2
Zinc finger protein AEBP2

1

17

High-throughput

0.445

High

148183

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

49406

A0PJE6
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.407

High

237235

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

4

High-throughput

0.407

High

456916

ANXA2
Annexin A2

1

5

High-throughput

0.407

High

459936

K2C4
Keratin, type II cytoskeletal 4

1

9

High-throughput

0.407

High

465817

ENPL
Endoplasmin

1

10

High-throughput

0.407

High

475789

K1C13
Keratin, type I cytoskeletal 13

1

15

High-throughput

0.407

High

550724

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.407

High

570335

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.407

High

602927

ENOA
Alpha-enolase

1

4

High-throughput

0.407

High

618529

FAS
Fatty acid synthase

1

3

High-throughput

0.407

High

619980

SERPH
Serpin H1

1

5

High-throughput

0.407

High

627473

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.407

High

628504

VIME
Vimentin

1

11

High-throughput

0.407

High

771707

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.407

High

772442

CALX
Calnexin

1

2

High-throughput

0.407

High

801628

HSPA9
Stress-70 protein, mitochondrial

1

10

High-throughput

0.407

High

844303

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.407

High

878139

ADT1
ADP/ATP translocase 1

1

7

High-throughput

0.407

High

893453

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

3

High-throughput

0.407

High

908581

ADT2
ADP/ATP translocase 2

1

7

High-throughput

0.407

High

920760

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

7

High-throughput

0.407

High

940828

ATPB
ATP synthase F(1) complex catalytic subunit beta, mitochondrial

1

6

High-throughput

0.407

High

945967

EF2
Elongation factor 2

1

3

High-throughput

0.407

High

949053

RUVB1
RuvB-like 1

1

8

High-throughput

0.407

High

985411

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.407

High

989449

CH60
60 kDa heat shock protein, mitochondrial

1

15

High-throughput

0.407

High

999764

IMB1
Importin subunit beta-1

1

6

High-throughput

0.407

High

1009920

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.407

High

1009952

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.407

High

1009986

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.407

High

1009996

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.407

High

1016696

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.407

High

1036149

PLAK
Junction plakoglobin

1

13

High-throughput

0.407

High

1042129

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

6

High-throughput

0.407

High

1052815

PYC
Pyruvate carboxylase, mitochondrial

1

4

High-throughput

0.407

High

1081344

K2C80
Keratin, type II cytoskeletal 80

1

8

High-throughput

0.407

High

1170034

Q20BD0
Heterogeneous nuclear ribonucleoprotein A/B

1

13

High-throughput

0.407

High

1189366

Q3TH47
Polyubiquitin-C

1

9

High-throughput

0.407

High

1190521

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.407

High

1191822

Q3ZAW8
Keratin 16

1

15

High-throughput

0.407

High

1210683

Q5SVJ0
calcium/calmodulin-dependent protein kinase

1

1

High-throughput

0.407

High

1211112

ACACA
Acetyl-CoA carboxylase 1

1

6

High-throughput

0.407

High

1222404

ARGI1
Arginase-1

1

2

High-throughput

0.407

High

1231041

K2C73
Keratin, type II cytoskeletal 73

1

8

High-throughput

0.407

High

1231042

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

4

High-throughput

0.407

High

1231044

Q6P9L1
Multifunctional protein CAD

1

4

High-throughput

0.407

High

1231045

Q71LX8
Heat shock protein 84b

1

10

High-throughput

0.407

High

1231047

Q7M754
trypsin

1

2

High-throughput

0.407

High

1231050

SEPT9
Septin-9

1

4

High-throughput

0.407

High

1231051

EFTU
Elongation factor Tu, mitochondrial

1

5

High-throughput

0.407

High

1231052

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

11

High-throughput

0.407

High

1231053

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

7

High-throughput

0.407

High

1231054

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

7

High-throughput

0.407

High

1231061

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.407

High

1231062

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

1

High-throughput

0.407

High

1231063

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.407

High

1231065

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

5

High-throughput

0.407

High

1231068

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

High-throughput

0.407

High

1231070

Q9CV95
Uncharacterized protein

1

16

High-throughput

0.407

High

1231071

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

5

High-throughput

0.407

High

1231073

U2AF1
Splicing factor U2AF 35 kDa subunit

1

3

High-throughput

0.407

High

1231074

RENT1
Regulator of nonsense transcripts 1

1

6

High-throughput

0.407

High

1231077

COPB
Coatomer subunit beta

1

3

High-throughput

0.407

High

1231078

RL38
Large ribosomal subunit protein eL38

1

2

High-throughput

0.407

High

1231080

K1C17
Keratin, type I cytoskeletal 17

1

13

High-throughput

0.407

High

1231081

PLEC
Plectin

1

7

High-throughput

0.407

High

1231084

RBMX
RNA-binding motif protein, X chromosome

1

11

High-throughput

0.407

High

1231085

NU160
Nuclear pore complex protein Nup160

1

1

High-throughput

0.407

High

609255

LYZ1
Lysozyme C-1

1

0

High-throughput

0.232

Low

664235

CATA
Catalase

1

0

High-throughput

0.232

Low

1197987

Q52L67
Gpsn2 protein

1

0

High-throughput

0.232

Low

1231075

GSDMA
Gasdermin-A

1

0

High-throughput

0.232

Low

1231079

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025