Protein: AP4E1
AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin)

Gene: AP4E1
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q9UPM8

Gene Ontology (top 5):
GO:0005802 - trans-Golgi network
GO:0006605 - protein targeting
GO:0006886 - intracellular protein transport
GO:0008104 - intracellular protein localization
GO:0016192 - vesicle-mediated transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1462475

AP4B1
AP-4 complex subunit beta-1

5

13

Small-scale

0.928

High

1462474

AP4S1
AP-4 complex subunit sigma-1

3

20

Small-scale

0.863

High

125857

AP4M1
AP-4 complex subunit mu-1

3

20

Small-scale

0.861

High

1014981

ARF1
ADP-ribosylation factor 1

2

20

Small-scale

0.783

High

1398739

AP4AT
AP-4 complex accessory subunit Tepsin

3

0

Small-scale

0.645

High

612332

ARF4
ADP-ribosylation factor 4

1

20

High-throughput

0.618

High

958835

ARF3
ADP-ribosylation factor 3

1

20

High-throughput

0.618

High

975323

ARF6
ADP-ribosylation factor 6

1

20

High-throughput

0.618

High

1015156

ARF5
ADP-ribosylation factor 5

1

20

High-throughput

0.618

High

1328735

FHI1B
FHF complex subunit HOOK-interacting protein 1B

2

1

Small-scale

0.558

High

1460581

HOOK1
Protein Hook homolog 1

2

7

Small-scale

0.558

High

1388882

HOOK2
Protein Hook homolog 2

1

11

Small-scale

0.536

High

1053466

FHI1A
FHF complex subunit HOOK-interacting protein 1A

2

1

Small-scale

0.533

High

136564

GOLI4
Golgi integral membrane protein 4

1

12

High-throughput

0.489

High

390215

ALBU
Albumin

1

1

High-throughput

0.489

High

431621

AP2A
Transcription factor AP-2-alpha

1

1

High-throughput

0.489

High

1291606

HOOK3
Protein Hook homolog 3

1

8

Small-scale

0.489

High

1428219

NDEL1
Nuclear distribution protein nudE-like 1

1

10

High-throughput

0.489

High

1448562

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.489

High

1452080

NDE1
Nuclear distribution protein nudE homolog 1

1

13

High-throughput

0.489

High

189930

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

218966

TGON2
Trans-Golgi network integral membrane protein 2

1

12

High-throughput

0.479

High

226265

STX6
Syntaxin-6

1

5

High-throughput

0.479

High

483262

CLCA
Clathrin light chain A

1

15

High-throughput

0.479

High

604273

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.479

High

631024

RAB4A
Ras-related protein Rab-4A

1

7

High-throughput

0.479

High

976667

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.479

High

1233581

LTOR1
Ragulator complex protein LAMTOR1

1

6

High-throughput

0.479

High

1276374

ATG9A
Autophagy-related protein 9A

1

6

High-throughput

0.479

High

1368973

GOGA1
Golgin subfamily A member 1

1

3

High-throughput

0.479

High

880983

MTR1B
Melatonin receptor type 1B

1

3

High-throughput

0.464

High

327502

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

173555

XPO1
Exportin-1

1

15

High-throughput

0.437

High

845362

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

4

High-throughput

0.437

High

920367

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.437

High

1031600

IFM3
Interferon-induced transmembrane protein 3

1

8

High-throughput

0.437

High

1229137

RNF43
E3 ubiquitin-protein ligase RNF43

1

5

High-throughput

0.437

High

1293208

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1356340

SMAP2
Stromal membrane-associated protein 2

1

11

High-throughput

0.437

High

1434239

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.437

High

1460301

XPO7
Exportin-7

1

15

High-throughput

0.437

High

1462476

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

3

High-throughput

0.437

High

116951

J3KNB8
Mitogen-activated protein kinase kinase kinase 4

1

5

High-throughput

0.407

High

1434605

SUV92
Histone-lysine N-methyltransferase SUV39H2

3

0

High-throughput

0.347

High

673794

LAMA1
Laminin subunit alpha-1

1

0

High-throughput

0.279

Low

1216539

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

1

0

High-throughput

0.279

Low

1403754

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.279

Low

1460009

DPOG2
DNA polymerase subunit gamma-2

1

0

High-throughput

0.279

Low

245369

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.249

Low

1436478

AKTIP
AKT-interacting protein

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025