HitPredict

Interactor 1: CO3 (P01027)
Complement C3 (HSE-MSF) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: CFAH (P06909)
Complement factor H (Protein beta-1-H)
Gene: Cfh

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16023208
Identification Methods	surface plasmon resonance
Interaction Type	physical association

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0006956 - complement activation GO:0006957 - complement activation, alternative pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1663 Mm			1 1234
+	Rn
		344734 CO3_RAT (1-1663): 0: 2171: 90.20		Q6MG73_RAT (1051-1233): 5.69e-11: 69.1: 17.91
+	Hs
		344624 CO3_HUMAN (1-1663): 0: 2084: 76.89		CFAH_HUMAN (1-387): 5.46e-35: 147: 20.81
+	Hs
		344619 CO3_HUMAN (1-1663): 0: 2084: 76.89		F13B_HUMAN (1-421): 3.6e-33: 139: 18.92
+	Hs
		344638 CO3_HUMAN (1-1663): 0: 2084: 76.89		CR2_HUMAN (5-279): 7.04e-32: 137: 21.60
+	Hs
		344697 CO3_HUMAN (1-1663): 0: 2084: 76.89		FHR4_HUMAN (871-1234): 6.06e-30: 128: 21.96
+	Hs
		344710 CO3_HUMAN (1-1663): 0: 2084: 76.89		FHR5_HUMAN (1-497): 1.02e-29: 127: 19.38
+	Hs
		344632 CO3_HUMAN (1-1663): 0: 2084: 76.89		MCP_HUMAN (326-567): 1.4e-14: 79.2: 19.84
+	Hs
		344636 CO3_HUMAN (1-1663): 0: 2084: 76.89		CR1_HUMAN (4-144): 7.92e-14: 78.9: 24.31
+	Hs
		344663 CO3_HUMAN (1-1663): 0: 2084: 76.89		FHR1_HUMAN (651-934): 8.54e-15: 78.9: 21.28
+	Hs
		344662 CO3_HUMAN (1-1663): 0: 2084: 76.89		FHR3_HUMAN (1-187): 1.08e-10: 66.6: 18.23
+	Hs
		341566 CO3_HUMAN (1-1663): 0: 2084: 76.89		CFAB_HUMAN (1119-1229): 8.25e-09: 62.2: 21.14
+	Hs
		469878 CO4A_HUMAN (20-1661): 0: 1592: 27.71		FHR4_HUMAN (871-1234): 6.06e-30: 128: 21.96
+	Hs
		469908 CO4B_HUMAN (20-1661): 0: 1592: 27.88		FHR4_HUMAN (871-1234): 6.06e-30: 128: 21.96
+	Hs
		416129 CO4A_HUMAN (20-1661): 0: 1592: 27.71		CO2_HUMAN (258-444): 1.15e-17: 90.7: 17.48
+	Hs
		416130 CO4B_HUMAN (20-1661): 0: 1592: 27.88		CO2_HUMAN (258-444): 1.15e-17: 90.7: 17.48
+	Hs
		469899 CO4B_HUMAN (20-1661): 0: 1592: 27.88		MCP_HUMAN (326-567): 1.4e-14: 79.2: 19.84
+	Hs
		344406 A2MG_HUMAN (20-1501): 0: 1388: 21.96		F13B_HUMAN (1-421): 3.6e-33: 139: 18.92