HitPredict

Interactor 1: TIMP1 (P01033)
Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)
Gene: TIMP1

Interactor 2: MMP9 (P14780)
Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
Gene: MMP9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.899

The method score is based on:

Property Details
Experiments 28514442, 33961781, 10895974, 19010413
Identification Methods affinity chromatography technology, protease assay, anti tag coimmunoprecipitation
Interaction Type physical association, enzymatic reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hemopexin~TIMP, Peptidase_M10~TIMP
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0008270 - zinc ion binding
GO:0043066 - negative regulation of apoptotic process
GO:0071492 - cellular response to UV-A
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 207
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Last updated: 15 Jul 2024