HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: H15 (P16401)
Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)
Gene: H1-5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29467282, 35013218
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 226
+	Hs
		345932 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H1T_HUMAN (1-214): 6.06e-27: 104: 50.00
+	Hs
		345851 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17
+	Mm
		348409 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		H15_MOUSE (39-205): 8.43e-21: 88.7: 92.81
+	Hs
		345775 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29
+	Hs
		346566 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Mm
		348408 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		H11_MOUSE (1-124): 1e-14: 72.1: 67.74
+	Hs
		379016 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		H1T_HUMAN (1-214): 6.06e-27: 104: 50.00
+	Hs
		378988 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		H15_HUMAN (1-118): 3.29e-18: 81.7: 100.00
+	Hs
		378989 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17
+	Hs
		378948 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29