HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: BRD8 (Q9H0E9)
Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120)
Gene: BRD8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	31753913, 35140242, 20946988
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 1235
+	Hs
		519730 MYCL_HUMAN (29-449): 4.2e-42: 154: 30.11		BRD8_HUMAN (1-1235): 0: 594: 100.00
+	Hs
		346644 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		BPTF_HUMAN (130-1222): 5.45e-42: 171: 9.55
+	Hs
		347493 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KAT2B_HUMAN (1075-1209): 2.89e-37: 154: 23.70
+	Hs
		348246 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TRI33_HUMAN (820-1232): 7.65e-33: 140: 11.56
+	Hs
		170198 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TIF1A_HUMAN (845-1228): 4.33e-31: 134: 14.07
+	Hs
		348175 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		BAZ2A_HUMAN (125-815): 2.72e-30: 132: 10.85
+	Hs
		347970 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		BRD7_HUMAN (1005-1212): 3.07e-29: 127: 15.02
+	Hs
		346630 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		EP300_HUMAN (807-1211): 2.38e-27: 123: 13.66
+	Mm
		348442 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		BRD8_MOUSE (850-1235): 3.98e-30: 131: 29.24
+	Hs
		347201 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PB1_HUMAN (987-1226): 1.89e-22: 107: 15.45
+	Hs
		345919 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TAF1_HUMAN (1002-1220): 5.29e-22: 105: 15.32
+	Hs
		346268 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMCA4_HUMAN (1057-1208): 7.26e-19: 95.5: 13.84
+	Hs
		347443 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PHIP_HUMAN (1059-1206): 1.19e-14: 81.5: 15.23
+	Hs
		347492 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KAT2A_HUMAN (684-810): 1.1e-12: 74.9: 17.32
+	Hs
		347489 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CBP_HUMAN (125-595): 9.03e-09: 62.2: 12.22
+	Hs
		379678 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		KAT2B_HUMAN (1075-1209): 2.89e-37: 154: 23.70
+	Hs
		379904 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		BRD7_HUMAN (1005-1212): 3.07e-29: 127: 15.02
+	Hs
		379333 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		EP300_HUMAN (807-1211): 2.38e-27: 123: 13.66
+	Hs
		379142 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMCA4_HUMAN (1057-1208): 7.26e-19: 95.5: 13.84
+	Hs
		297832 K0754_HUMAN (47-360): 3.79e-40: 156: 12.62		BRWD3_HUMAN (1048-1232): 1.82e-19: 97.4: 18.18