HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 976
+	Hs
		349903 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		665242 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		350187 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA7_HUMAN (4-974): 0: 1128: 50.30
+	Hs
		1070202 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHA7_HUMAN (4-974): 0: 1128: 50.30
+	Hs
		350003 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		348673 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		EPHA7_HUMAN (4-974): 0: 1128: 50.30
+	Hs
		349904 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA3_HUMAN (24-976): 0: 1111: 51.19
+	Hs
		665398 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHA3_HUMAN (24-976): 0: 1111: 51.19
+	Hs
		348528 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		EPHA3_HUMAN (24-976): 0: 1111: 51.19
+	Hs
		349905 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHB2_HUMAN (28-973): 0: 1089: 48.29
+	Hs
		665604 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHB2_HUMAN (28-973): 0: 1089: 48.29
+	Hs
		350002 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHB4_HUMAN (14-970): 0: 986: 44.99
+	Hs
		872534 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHB4_HUMAN (14-970): 0: 986: 44.99
+	Hs
		349876 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA1_HUMAN (17-967): 0: 959: 49.38
+	Hs
		349800 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		INSR_HUMAN (281-933): 1.71e-136: 445: 24.85
+	Hs
		349808 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		348472 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		INSR_HUMAN (281-933): 1.71e-136: 445: 24.85
+	Hs
		349807 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433769 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		348474 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91