HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: VAMP8 (Q9BV40)
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Gene: VAMP8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30442766
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome GO:0070821 - tertiary granule membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 100
+	Hs
		349991 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		850565 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		261627 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		261663 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		350196 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		894738 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		350502 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		VAMP8_HUMAN (1-100): 2.94e-24: 89.6: 100.00
+	Hs
		350050 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Hs
		1070209 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		348586 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		926209 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Hs
		349205 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		261626 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		348681 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		348604 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Hs
		349343 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		349606 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		VAMP8_HUMAN (1-100): 2.94e-24: 89.6: 100.00
+	Hs
		349234 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Hs
		918878 RAB1A_HUMAN (4-187): 1.35e-76: 229: 33.33		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		1079428 RAB1B_HUMAN (4-187): 1.35e-75: 226: 33.51		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99