HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: AGAP1 (Q9UPQ3)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)
Gene: AGAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras, Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 857
+	Hs
		350689 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		AGAP1_HUMAN (1-857): 0: 850: 100.00
+	Hs
		1070459 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		AGAP1_HUMAN (1-857): 0: 850: 100.00
+	Hs
		894736 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		ACAP2_HUMAN (308-854): 7.28e-132: 414: 16.55
+	Hs
		1066121 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		ACAP2_HUMAN (308-854): 7.28e-132: 414: 16.55
+	Mm
		1186345 RAB1B_MOUSE (4-187): 2e-75: 226: 32.47		ASAP2_MOUSE (367-855): 3.55e-96: 324: 19.77
+	Hs
		349517 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		ASAP3_HUMAN (367-854): 3.9e-84: 290: 18.48
+	Hs
		350406 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Hs
		349535 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Zm
		73944 B4FAE1_MAIZE (4-187): 1.88e-80: 239: 32.65		B4FAE1_MAIZE (68-273): 7.21e-79: 255: 21.13
+	Hs
		350037 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		894715 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		918874 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Mm
		918986 RAB35_MOUSE (4-171): 6.96e-84: 247: 34.71		RAB1A_MOUSE (72-257): 3.27e-72: 237: 24.35
+	Hs
		348601 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		349231 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		918916 RAB2B_HUMAN (4-185): 2.66e-77: 231: 32.61		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		918846 RAB1A_HUMAN (4-187): 1.35e-76: 229: 33.33		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		918944 RAB1B_HUMAN (4-187): 1.35e-75: 226: 33.51		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Mm
		919000 RAB1B_MOUSE (4-187): 2e-75: 226: 32.47		RAB1A_MOUSE (72-257): 3.27e-72: 237: 24.35
+	Hs
		897876 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75