Protein: ROCK2
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)

Gene: ROCK2
Organism: Homo sapiens
Interactions: 130
UniProt ID: O75116

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0001837 - epithelial to mesenchymal transition
GO:0001934 - positive regulation of protein phosphorylation
GO:0002020 - protease binding
GO:0002931 - response to ischemia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

270786

KS6A3
Ribosomal protein S6 kinase alpha-3

3

10

High-throughput

0.871

High

270804

ROCK1
Rho-associated protein kinase 1

3

19

High-throughput

0.861

High

270854

DJB11
DnaJ homolog subfamily B member 11

3

6

High-throughput

0.861

High

193474

PDPK1
3-phosphoinositide-dependent protein kinase 1

3

19

High-throughput

0.839

High

270754

RASK
GTPase KRas

3

20

High-throughput

0.827

High

270791

RHOA
Transforming protein RhoA

3

20

Small-scale

0.827

High

270752

RASN
GTPase NRas

2

20

High-throughput

0.754

High

270793

RB11A
Ras-related protein Rab-11A

2

6

High-throughput

0.754

High

270794

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

270763

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

17

Small-scale

0.724

High

270813

CDKN3
Cyclin-dependent kinase inhibitor 3

1

2

Small-scale

0.724

High

270761

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

2

Small-scale

0.713

High

270747

DNJC8
DnaJ homolog subfamily C member 8

1

4

High-throughput

0.691

High

270784

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

1

High-throughput

0.691

High

270829

ZN444
Zinc finger protein 444

1

2

High-throughput

0.691

High

270831

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.691

High

270834

ANR49
Ankyrin repeat domain-containing protein 49

1

5

High-throughput

0.691

High

270836

SGK3
Serine/threonine-protein kinase Sgk3

1

17

High-throughput

0.691

High

270840

ZN641
Zinc finger protein 641

1

2

High-throughput

0.691

High

270843

DUS16
Dual specificity protein phosphatase 16

1

5

High-throughput

0.691

High

74410

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

10

High-throughput

0.665

High

270745

STK16
Serine/threonine-protein kinase 16

1

15

High-throughput

0.665

High

270808

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

19

High-throughput

0.665

High

180187

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

3

High-throughput

0.628

High

270779

ADDB
Beta-adducin

2

5

High-throughput

0.628

High

126397

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

240257

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.618

High

253259

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

270744

ROCK2
Rho-associated protein kinase 2

1

16

High-throughput

0.618

High

270748

RHBT1
Rho-related BTB domain-containing protein 1

1

20

Small-scale

0.618

High

270751

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.618

High

270753

RASH
GTPase HRas

1

18

High-throughput

0.618

High

270755

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.618

High

270757

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

270766

FGFR1
Fibroblast growth factor receptor 1

1

14

High-throughput

0.618

High

270769

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

270771

NUCL
Nucleolin

1

9

Small-scale

0.618

High

270775

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.618

High

270783

MUC18
Cell surface glycoprotein MUC18

1

10

High-throughput

0.618

High

270787

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.618

High

270789

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

270790

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.618

High

270795

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

270800

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

270812

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

270816

RHG21
Rho GTPase-activating protein 21

1

2

High-throughput

0.618

High

270824

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

270845

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

270846

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

270848

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

270776

AMRP
Alpha-2-macroglobulin receptor-associated protein

2

0

High-throughput

0.602

High

270839

LURA1
Leucine rich adaptor protein 1

2

8

High-throughput

0.601

High

270749

MRP6
ATP-binding cassette sub-family C member 6

1

0

Small-scale

0.586

High

270765

LAMP1
Lysosome-associated membrane glycoprotein 1

2

7

High-throughput

0.584

High

270802

EP300
Histone acetyltransferase p300

2

10

Small-scale

0.584

High

270815

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.575

High

270822

FBX42
F-box only protein 42

2

3

High-throughput

0.574

High

270750

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

5

Small-scale

0.571

High

270758

LEG1
Galectin-1

1

1

High-throughput

0.536

High

270759

CLCB
Clathrin light chain B

1

2

High-throughput

0.536

High

270780

AHR
Aryl hydrocarbon receptor

1

5

High-throughput

0.536

High

270803

AKP13
A-kinase anchor protein 13

1

13

High-throughput

0.536

High

270805

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.536

High

270806

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

270826

MILR1
Allergin-1

1

3

High-throughput

0.536

High

270830

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.536

High

270832

BBS1
BBSome complex member BBS1

1

2

High-throughput

0.536

High

270842

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

270844

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.536

High

270847

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

3

High-throughput

0.536

High

270851

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.536

High

270857

FBX2
F-box only protein 2

1

2

High-throughput

0.536

High

270781

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.515

High

270814

H2B2E
Histone H2B type 2-E

1

14

High-throughput

0.515

High

270756

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

261744

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.513

High

270821

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.513

High

270825

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.513

High

270833

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

270797

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.501

High

270799

HTRA3
Serine protease HTRA3

1

2

High-throughput

0.489

High

270823

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.489

High

270835

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.489

High

270856

EGFL7
Epidermal growth factor-like protein 7

1

5

High-throughput

0.489

High

254460

MAGC1
Melanoma-associated antigen C1

1

5

Small-scale

0.481

High

138420

BIN1
Myc box-dependent-interacting protein 1

1

3

High-throughput

0.479

High

217604

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

270762

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.479

High

270764

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.479

High

270767

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

270768

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

270770

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

270772

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.479

High

270774

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.479

High

270782

PERI
Peripherin

1

16

High-throughput

0.479

High

270792

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

270796

KCNJ2
Inward rectifier potassium channel 2

1

1

Small-scale

0.479

High

270798

H31
Histone H3.1

1

8

High-throughput

0.479

High

270801

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

270807

CUL3
Cullin-3

1

7

High-throughput

0.479

High

270809

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

270810

EEA1
Early endosome antigen 1

1

14

High-throughput

0.479

High

270811

TRIP4
Activating signal cointegrator 1

1

1

High-throughput

0.479

High

270817

TASO2
Protein TASOR 2

1

5

High-throughput

0.479

High

270819

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

270820

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

270828

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

9

Small-scale

0.479

High

270838

OPTN
Optineurin

1

19

High-throughput

0.479

High

270850

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.479

High

270853

DAPLE
Protein Daple

1

17

High-throughput

0.479

High

270855

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

270858

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

High-throughput

0.479

High

270859

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.479

High

270860

SNX9
Sorting nexin-9

1

2

High-throughput

0.479

High

270746

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

Small-scale

0.458

High

270785

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

270849

LZTL1
Leucine zipper transcription factor-like protein 1

1

0

High-throughput

0.458

High

270777

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

270837

PP14B
Protein phosphatase 1 regulatory subunit 14B

1

1

Small-scale

0.445

High

270852

SPHK1
Sphingosine kinase 1

1

1

Small-scale

0.445

High

104936

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

270778

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

270760

GOG8G
Golgin subfamily A member 8G

1

20

High-throughput

0.407

High

270773

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

270841

SFXN2
Sideroflexin-2

1

2

High-throughput

0.407

High

270818

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

270827

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.249

Low

62430

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

270788

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025