Protein: PTPRF
Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)

Gene: PTPRF
Organism: Homo sapiens
Interactions: 236
UniProt ID: P10586

Gene Ontology (top 5):
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0007155 - cell adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

522656

LIPA1
Liprin-alpha-1

4

11

Small-scale

0.898

High

262202

SCN2B
Sodium channel regulatory subunit beta-2

4

8

High-throughput

0.892

High

362658

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.883

High

440313

FYN
Tyrosine-protein kinase Fyn

3

20

Small-scale

0.858

High

522662

I13R2
Interleukin-13 receptor subunit alpha-2

2

18

High-throughput

0.811

High

522635

RHOA
Transforming protein RhoA

2

20

Small-scale

0.800

High

522644

TBB4B
Tubulin beta-4B chain

2

1

Small-scale

0.793

High

522601

RYK
Tyrosine-protein kinase RYK

2

20

Small-scale

0.789

High

522610

TGFR2
TGF-beta receptor type-2

2

6

High-throughput

0.789

High

71377

HECA2
HEPACAM family member 2

3

15

High-throughput

0.770

High

522673

CEA21
Cell adhesion molecule CEACAM21

3

14

High-throughput

0.770

High

299508

TRIO
Triple functional domain protein

2

2

Small-scale

0.754

High

522723

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

4

High-throughput

0.726

High

439918

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.724

High

177360

ARHGB
Rho guanine nucleotide exchange factor 11

1

7

Small-scale

0.713

High

270761

ROCK2
Rho-associated protein kinase 2

1

2

Small-scale

0.713

High

276359

LIPA2
Liprin-alpha-2

1

13

Small-scale

0.713

High

522630

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.713

High

522748

ARHGC
Rho guanine nucleotide exchange factor 12

1

6

Small-scale

0.713

High

522646

KC1G2
Casein kinase I isoform gamma-2

1

4

High-throughput

0.691

High

522652

CD83
CD83 antigen

1

1

High-throughput

0.691

High

522658

AVR2B
Activin receptor type-2B

1

6

High-throughput

0.691

High

522676

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

1

High-throughput

0.691

High

522686

BT2A1
Butyrophilin subfamily 2 member A1

1

4

High-throughput

0.691

High

522714

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

18

High-throughput

0.691

High

522753

CLC4A
C-type lectin domain family 4 member A

1

6

High-throughput

0.691

High

522715

ARHG2
Rho guanine nucleotide exchange factor 2

1

5

Small-scale

0.662

High

522697

SH2D3
SH2 domain-containing protein 3C

2

20

High-throughput

0.659

High

522647

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.656

High

522605

CTNB1
Catenin beta-1

3

19

Small-scale

0.656

High

158525

NCAN
Neurocan core protein

1

3

Small-scale

0.647

High

283647

GPC4
Glypican-4

1

8

Small-scale

0.647

High

463885

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.647

High

522581

CSPG2
Versican core protein

1

4

Small-scale

0.647

High

522582

NID1
Nidogen-1

1

2

Small-scale

0.647

High

522592

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

16

Small-scale

0.647

High

522593

OMGP
Oligodendrocyte-myelin glycoprotein

1

6

Small-scale

0.647

High

522575

CLUS
Clusterin

2

2

High-throughput

0.628

High

522674

CC50B
Cell cycle control protein 50B

2

2

High-throughput

0.628

High

522695

PIANP
PILR alpha-associated neural protein

2

1

High-throughput

0.628

High

522721

MRAP2
Melanocortin-2 receptor accessory protein 2

2

2

High-throughput

0.628

High

522743

PCDBG
Protocadherin beta-16

2

19

High-throughput

0.628

High

522762

PCDGD
Protocadherin gamma-B1

2

19

High-throughput

0.628

High

522624

FCGRN
IgG receptor FcRn large subunit p51

1

5

High-throughput

0.618

High

522740

LRTM1
Leucine-rich repeat and transmembrane domain-containing protein 1

1

10

High-throughput

0.618

High

522750

OPT
Opticin

1

7

High-throughput

0.618

High

126445

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

374358

RASH
GTPase HRas

1

13

High-throughput

0.618

High

375115

RASK
GTPase KRas

1

18

High-throughput

0.618

High

410550

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

411245

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

466080

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

507453

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.618

High

522584

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

522588

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

522604

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

8

High-throughput

0.618

High

522607

BASI
Basigin

1

8

High-throughput

0.618

High

522608

BMR1A
Bone morphogenetic protein receptor type-1A

1

6

High-throughput

0.618

High

522617

MUC18
Cell surface glycoprotein MUC18

1

13

High-throughput

0.618

High

522620

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.618

High

522621

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

522631

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

522632

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

522633

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.618

High

522636

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

522639

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

522641

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

522650

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

522657

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

17

High-throughput

0.618

High

522666

RAB35
Ras-related protein Rab-35

1

5

High-throughput

0.618

High

522667

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

522670

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

16

High-throughput

0.618

High

522687

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

522711

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

522712

ESR2
Estrogen receptor beta

1

1

High-throughput

0.618

High

522736

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

522739

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

522756

GIT1
ARF GTPase-activating protein GIT1

1

2

Small-scale

0.618

High

522637

HNRPK
Heterogeneous nuclear ribonucleoprotein K

3

0

High-throughput

0.613

High

522749

MARH2
E3 ubiquitin-protein ligase MARCHF2

2

7

High-throughput

0.611

High

522661

WFDC2
WAP four-disulfide core domain protein 2

2

0

High-throughput

0.602

High

522654

CAV1
Caveolin-1

2

1

Small-scale

0.601

High

522764

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

3

High-throughput

0.601

High

522583

PLAK
Junction plakoglobin

2

20

Small-scale

0.595

High

484029

PGFRB
Platelet-derived growth factor receptor beta

1

15

High-throughput

0.575

High

522587

CTLA4
Cytotoxic T-lymphocyte protein 4

1

3

High-throughput

0.575

High

522671

MICB
MHC class I polypeptide-related sequence B

1

6

High-throughput

0.575

High

522698

LRC52
Leucine-rich repeat-containing protein 52

1

4

High-throughput

0.575

High

522700

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.575

High

522705

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

2

High-throughput

0.575

High

522738

MANS1
MANSC domain-containing protein 1

2

1

High-throughput

0.574

High

522699

RN149
E3 ubiquitin-protein ligase RNF149

2

8

High-throughput

0.558

High

271612

LIPA3
Liprin-alpha-3

1

11

Small-scale

0.555

High

522643

TBA1B
Tubulin alpha-1B chain

1

1

Small-scale

0.555

High

522677

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

5

Small-scale

0.555

High

522685

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.553

High

522648

DLK1
Protein delta homolog 1

2

8

High-throughput

0.549

High

522574

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

16

Small-scale

0.545

High

139644

DLL1
Delta-like protein 1

1

3

High-throughput

0.536

High

165890

FFAR1
Free fatty acid receptor 1

1

4

High-throughput

0.536

High

275801

CAD16
Cadherin-16

1

20

High-throughput

0.536

High

522603

CNR2
Cannabinoid receptor 2

1

2

Small-scale

0.536

High

522609

TNR3
Tumor necrosis factor receptor superfamily member 3

1

8

High-throughput

0.536

High

522616

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

5

High-throughput

0.536

High

522660

KCNC3
Voltage-gated potassium channel KCNC3

1

4

High-throughput

0.536

High

522669

SGCA
Alpha-sarcoglycan

1

2

High-throughput

0.536

High

522680

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.536

High

522684

I20RB
Interleukin-20 receptor subunit beta

1

4

High-throughput

0.536

High

522689

T150A
Transmembrane protein 150A

1

1

High-throughput

0.536

High

522696

IZUM1
Izumo sperm-egg fusion protein 1

1

1

High-throughput

0.536

High

522701

ARRD4
Arrestin domain-containing protein 4

1

4

High-throughput

0.536

High

522702

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

7

High-throughput

0.536

High

522703

PKR1
Prokineticin receptor 1

1

5

High-throughput

0.536

High

522716

I22R2
Interleukin-22 receptor subunit alpha-2

1

4

High-throughput

0.536

High

522717

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

3

High-throughput

0.536

High

522719

ARRD3
Arrestin domain-containing protein 3

1

4

High-throughput

0.536

High

522720

TSN17
Tetraspanin-17

1

6

High-throughput

0.536

High

522725

OPALI
Opalin

1

1

High-throughput

0.536

High

522728

SYT11
Synaptotagmin-11

1

1

High-throughput

0.536

High

522734

PCDC1
Protocadherin alpha-C1

1

20

High-throughput

0.536

High

522741

PCD12
Protocadherin-12

1

20

High-throughput

0.536

High

522747

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.536

High

522754

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

6

High-throughput

0.536

High

522760

RNF11
RING finger protein 11

1

7

High-throughput

0.536

High

252408

DIAP1
Protein diaphanous homolog 1

1

0

Small-scale

0.529

High

522622

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

Small-scale

0.529

High

522706

DEP1B
DEP domain-containing protein 1B

1

2

Small-scale

0.527

High

522589

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.514

High

522626

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

2

High-throughput

0.514

High

522625

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.513

High

522651

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

522710

BSND
Barttin

1

0

High-throughput

0.513

High

522742

NPDC1
Neural proliferation differentiation and control protein 1

1

0

High-throughput

0.513

High

280475

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.508

High

522640

H4
Histone H4

1

0

High-throughput

0.493

High

522708

RN133
E3 ubiquitin-protein ligase RNF133

1

8

High-throughput

0.489

High

522709

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

1

High-throughput

0.489

High

522737

TM231
Transmembrane protein 231

1

1

High-throughput

0.489

High

522746

CLDN1
Claudin domain-containing protein 1

1

2

High-throughput

0.489

High

522578

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

358588

LDHA
L-lactate dehydrogenase A chain

1

1

Small-scale

0.481

High

407831

SEMG1
Semenogelin-1

1

1

Small-scale

0.481

High

450910

LDHB
L-lactate dehydrogenase B chain

1

1

Small-scale

0.481

High

522576

BIP
Endoplasmic reticulum chaperone BiP

1

2

Small-scale

0.481

High

522577

HSP7C
Heat shock cognate 71 kDa protein

1

1

Small-scale

0.481

High

522594

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

Small-scale

0.481

High

522597

EF1G
Elongation factor 1-gamma

1

1

Small-scale

0.481

High

522602

HS71L
Heat shock 70 kDa protein 1-like

1

1

Small-scale

0.481

High

522611

HSPA9
Stress-70 protein, mitochondrial

1

3

Small-scale

0.481

High

522653

SEMG2
Semenogelin-2

1

1

Small-scale

0.481

High

217752

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

522579

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

522580

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

522598

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

522606

IRS1
Insulin receptor substrate 1

1

6

Small-scale

0.479

High

522627

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.479

High

522638

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

522683

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

522688

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.479

High

522718

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

522729

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.479

High

522735

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

522693

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.470

High

408632

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.460

High

461067

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.460

High

522586

CBR1
Carbonyl reductase [NADPH] 1

1

0

Small-scale

0.460

High

522596

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

0

Small-scale

0.460

High

522642

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.460

High

522713

CBP
CREB-binding protein

1

0

Small-scale

0.460

High

209450

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.458

High

522727

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

522732

NAA50
N-alpha-acetyltransferase 50

1

0

High-throughput

0.458

High

133053

EAA5
Excitatory amino acid transporter 5

1

4

High-throughput

0.445

High

160982

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

5

High-throughput

0.445

High

254765

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

388358

B3AT
Band 3 anion transport protein

1

1

High-throughput

0.445

High

480660

LEG1
Galectin-1

1

20

High-throughput

0.445

High

522590

CD9
CD9 antigen

1

6

High-throughput

0.445

High

522595

ACKR3
Atypical chemokine receptor 3

1

6

High-throughput

0.445

High

522613

S19A1
Reduced folate transporter

1

1

High-throughput

0.445

High

522614

EAA1
Excitatory amino acid transporter 1

1

4

High-throughput

0.445

High

522615

EAA2
Excitatory amino acid transporter 2

1

4

High-throughput

0.445

High

522618

S6A12
Sodium- and chloride-dependent betaine transporter

1

6

High-throughput

0.445

High

522619

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

6

High-throughput

0.445

High

522628

CD81
CD81 antigen

1

6

High-throughput

0.445

High

522659

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

522664

NTCP
Hepatic sodium/bile acid cotransporter

1

4

High-throughput

0.445

High

522672

SOAT
Sodium-dependent organic anion transporter

1

4

High-throughput

0.445

High

522730

S19A3
Thiamine transporter 2

1

1

High-throughput

0.445

High

522731

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

522755

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

522758

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

6

High-throughput

0.445

High

522763

PCDG5
Protocadherin gamma-A5

1

20

High-throughput

0.445

High

413067

P53
Cellular tumor antigen p53

1

1

High-throughput

0.437

High

522599

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

522600

PML
Protein PML

1

2

High-throughput

0.437

High

522629

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.437

High

522645

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

522665

CUL7
Cullin-7

1

1

High-throughput

0.437

High

522679

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

7

High-throughput

0.437

High

522690

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

7

High-throughput

0.437

High

522704

RN128
E3 ubiquitin-protein ligase RNF128

1

8

High-throughput

0.437

High

522752

XPO7
Exportin-7

1

11

High-throughput

0.437

High

522757

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.437

High

522761

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

126972

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

522655

NPT2A
Sodium-dependent phosphate transport protein 2A

1

0

High-throughput

0.426

High

522668

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

High-throughput

0.426

High

522682

TMM88
Transmembrane protein 88

1

0

High-throughput

0.426

High

522691

OSTA
Organic solute transporter subunit alpha

1

0

High-throughput

0.426

High

522733

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.426

High

522678

NTCP5
Sodium/bile acid cotransporter 5

1

4

High-throughput

0.407

High

522681

NPAL3
NIPA-like protein 3

1

4

High-throughput

0.407

High

522692

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

1

High-throughput

0.407

High

522759

ZDHC9
Palmitoyltransferase ZDHHC9

1

1

High-throughput

0.407

High

186463

VA0E1
V-type proton ATPase subunit e 1

2

0

High-throughput

0.328

High

522751

SEPT9
Septin-9

1

0

Small-scale

0.288

High

522675

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.279

Low

522707

TM171
Transmembrane protein 171

1

0

High-throughput

0.279

Low

522722

CYYR1
Cysteine and tyrosine-rich protein 1

1

0

High-throughput

0.279

Low

522745

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

522724

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.265

Low

522649

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

Small-scale

0.251

Low

71281

F1712
Protein FAM171A2

1

0

High-throughput

0.249

Low

188564

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.249

Low

208013

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.249

Low

522585

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

522612

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

522623

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

522634

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

522663

NC2A
Dr1-associated corepressor

1

0

High-throughput

0.249

Low

522726

FDXA1
Ferredoxin-fold anticodon-binding domain-containing protein 1

1

0

High-throughput

0.249

Low

522744

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.249

Low

522591

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

522694

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025