HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.966

The method score is based on:

Property Details
Experiments 27213482, 27684187, 30442766, 30639242, 30194290, 32591521, 26051715
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, proximity labelling technology, protein complementation assay, dynamic light scattering, classical fluorescence spectroscopy, nuclear magnetic resonance, isothermal titration calorimetry, microscale thermophoresis
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ras~Ras
Common GO terms GO:0000139 - Golgi membrane
GO:0000165 - MAPK cascade
GO:0001934 - positive regulation of protein phosphorylation
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
and 32 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 189
Hs

1 189
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024