HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 901
+	Hs
		349259 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		348626 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		971013 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		895046 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		914018 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		349322 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		348666 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		350172 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		349094 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		349835 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		521847 RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		919689 RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08		PCDA8_HUMAN (358-864): 2.34e-50: 193: 13.02
+	Hs
		349315 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		348660 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		1048587 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		350163 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		895075 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		914063 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Cl
		94527 RAB1A_CANLF (4-187): 7.4e-74: 222: 34.36		CADH1_CANLF (24-261): 1.71e-16: 86.6: 15.30