HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: RHG01 (Q07960)
Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)
Gene: ARHGAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 439
+	Hs
		348636 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00
+	Hs
		993020 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00
+	Hs
		895053 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00
+	Hs
		914029 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00
+	Hs
		349384 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08
+	Hs
		1070234 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08
+	Hs
		350234 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08
+	Hs
		895119 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08
+	Hs
		64708 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		RHG32_HUMAN (180-433): 7.32e-64: 225: 21.56
+	Hs
		350207 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		RHG31_HUMAN (234-439): 3.47e-66: 231: 25.81
+	Hs
		350325 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		RHG12_HUMAN (196-432): 5.78e-66: 228: 22.92
+	Hs
		64637 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		RHG32_HUMAN (180-433): 7.32e-64: 225: 21.56
+	Hs
		914040 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		BNIP2_HUMAN (4-228): 1.04e-71: 230: 29.46
+	Hs
		895065 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		MYO9B_HUMAN (235-427): 3.06e-18: 89.7: 30.96