HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: NECT2 (Q92692)
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
Gene: NECTIN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	30442766, 30639242, 30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 538
+	Hs
		349539 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NECT2_HUMAN (1-538): 1.67e-89: 287: 100.00
+	Hs
		348836 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		NECT2_HUMAN (1-538): 1.67e-89: 287: 100.00
+	Hs
		1070332 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		NECT2_HUMAN (1-538): 1.67e-89: 287: 100.00
+	Hs
		348943 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		NECT3_HUMAN (30-389): 3.83e-72: 241: 25.00
+	Hs
		349617 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		CADM1_HUMAN (40-348): 2.54e-66: 223: 20.25
+	Hs
		349330 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NECT1_HUMAN (19-370): 6.64e-58: 203: 34.72
+	Hs
		348671 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		NECT1_HUMAN (19-370): 6.64e-58: 203: 34.72
+	Hs
		211414 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		SIGL6_HUMAN (35-396): 6.47e-54: 190: 17.02
+	Hs
		349096 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NCAM1_HUMAN (33-529): 2.22e-37: 149: 13.30
+	Hs
		348489 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		NCAM1_HUMAN (33-529): 2.22e-37: 149: 13.30
+	Hs
		349286 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PTK7_HUMAN (4-527): 3.59e-35: 142: 14.13
+	Hs
		348643 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PTK7_HUMAN (4-527): 3.59e-35: 142: 14.13
+	Hs
		530172 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		NCAM1_HUMAN (33-529): 2.22e-37: 149: 13.30
+	Hs
		349775 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ROBO1_HUMAN (333-538): 1.79e-18: 91.7: 8.92
+	Hs
		349043 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		ROBO1_HUMAN (333-538): 1.79e-18: 91.7: 8.92
+	Hs
		349572 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		KIRR1_HUMAN (33-363): 7.38e-16: 82.9: 16.72
+	Hs
		1070491 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ROBO1_HUMAN (333-538): 1.79e-18: 91.7: 8.92
+	Hs
		348867 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		KIRR1_HUMAN (33-363): 7.38e-16: 82.9: 16.72
+	Hs
		1070344 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		KIRR1_HUMAN (33-363): 7.38e-16: 82.9: 16.72
+	Hs
		348808 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		CADM4_HUMAN (267-538): 2.9e-12: 70.5: 11.03