Protein: ABD12
Lysophosphatidylserine lipase ABHD12 (EC 3.1.-.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (hABHD12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-)

Gene: ABD12, ABHD12
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q8N2K0

Gene Ontology (top 5):
GO:0004620 - phospholipase activity
GO:0004622 - phosphatidylcholine lysophospholipase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006660 - phosphatidylserine catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

173989

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

2

2

High-throughput

0.789

High

1324377

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.691

High

1242859

S39A4
Zinc transporter ZIP4

4

7

High-throughput

0.691

High

1197826

S39AC
Zinc transporter ZIP12

4

7

High-throughput

0.687

High

828402

PEX19
Peroxisomal biogenesis factor 19

3

0

High-throughput

0.638

High

182656

GP182
G-protein coupled receptor 182

2

12

High-throughput

0.633

High

1287266

DPP9
Dipeptidyl peptidase 9

3

2

High-throughput

0.604

High

1324373

SPP2B
Signal peptide peptidase-like 2B

2

2

High-throughput

0.601

High

242262

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

341331

ECEL1
Endothelin-converting enzyme-like 1

2

0

High-throughput

0.576

High

418262

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

0

High-throughput

0.559

High

951258

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

1324382

SAAL1
Protein SAAL1

2

1

High-throughput

0.549

High

252944

UD19
UDP-glucuronosyltransferase 1A9

1

1

High-throughput

0.536

High

380316

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

3

High-throughput

0.536

High

438898

CD1A
T-cell surface glycoprotein CD1a

1

1

High-throughput

0.536

High

595075

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

1

High-throughput

0.536

High

698873

CALX
Calnexin

1

1

High-throughput

0.536

High

905620

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

956938

CXCR4
C-X-C chemokine receptor type 4

1

8

High-throughput

0.536

High

1009155

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

3

High-throughput

0.536

High

1116245

PTC1
Protein patched homolog 1

1

2

High-throughput

0.536

High

1180911

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

1

3

High-throughput

0.536

High

1226405

TBC9B
TBC1 domain family member 9B

1

1

High-throughput

0.536

High

1244881

NCEH1
Neutral cholesterol ester hydrolase 1

1

1

High-throughput

0.536

High

1324374

AQP3
Aquaporin-3

1

3

High-throughput

0.536

High

1324393

SG196
Protein O-mannose kinase

1

2

High-throughput

0.536

High

1324395

UD17
UDP-glucuronosyltransferase 1A7

1

1

High-throughput

0.536

High

260908

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

548059

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

575677

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.513

High

1187400

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.513

High

1324378

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

1324390

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1324403

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.513

High

1324404

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.513

High

412250

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.500

High

1115809

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.494

High

1236106

FSTL4
Follistatin-related protein 4

1

1

High-throughput

0.489

High

1289353

ST32C
Serine/threonine-protein kinase 32C

1

1

High-throughput

0.489

High

1310220

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.489

High

1324389

KLK15
Kallikrein-15

1

2

High-throughput

0.489

High

374048

RASN
GTPase NRas

1

1

High-throughput

0.479

High

375709

RASK
GTPase KRas

1

1

High-throughput

0.479

High

788960

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.479

High

791526

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

1308156

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1324379

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1324381

PLD4
5'-3' exonuclease PLD4

1

1

High-throughput

0.479

High

1324385

CALR3
Calreticulin-3

1

1

High-throughput

0.479

High

1324392

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

218449

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

417572

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

582589

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.458

High

820686

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

1163372

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

1249013

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1252125

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1252891

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1324386

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1324388

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1324398

DJB12
DnaJ homolog subfamily B member 12

1

0

High-throughput

0.458

High

1324399

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

256082

S19A2
Thiamine transporter 1

1

2

High-throughput

0.445

High

379548

IGHM
Immunoglobulin heavy constant mu

1

1

High-throughput

0.445

High

722528

CTR1
High affinity cationic amino acid transporter 1

1

5

High-throughput

0.445

High

869623

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

2

High-throughput

0.445

High

870263

S6A12
Sodium- and chloride-dependent betaine transporter

1

2

High-throughput

0.445

High

1093543

TRDN
Triadin

1

1

High-throughput

0.445

High

1139495

S39AE
Metal cation symporter ZIP14

1

7

High-throughput

0.445

High

1236216

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1271243

SV2B
Synaptic vesicle glycoprotein 2B

1

6

High-throughput

0.445

High

1323720

S39AB
Zinc transporter ZIP11

1

7

High-throughput

0.445

High

1324372

S7A14
Solute carrier family 7 member 14

1

5

High-throughput

0.445

High

1324375

S39A7
Zinc transporter SLC39A7

1

7

High-throughput

0.445

High

1324402

S39AA
Zinc transporter ZIP10

1

7

High-throughput

0.445

High

106255

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

343981

HS74L
Heat shock 70 kDa protein 4L

1

4

High-throughput

0.437

High

695928

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

970768

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

1238734

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1254614

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1324371

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.437

High

1324376

HS105
Heat shock protein 105 kDa

1

4

High-throughput

0.437

High

1324384

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1324394

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

1324400

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

248910

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

538782

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

0

High-throughput

0.426

High

1180287

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

1324383

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.426

High

1324405

5MP1
eIF5-mimic protein 1

1

0

High-throughput

0.426

High

51454

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

7

High-throughput

0.407

High

1324370

SVOP
Synaptic vesicle 2-related protein

1

5

High-throughput

0.407

High

1324391

CPVL
Probable serine carboxypeptidase CPVL

2

0

High-throughput

0.328

High

191450

SIA8E
Alpha-2,8-sialyltransferase 8E

1

0

High-throughput

0.279

Low

355370

B3GT4
Beta-1,3-galactosyltransferase 4

1

0

High-throughput

0.279

Low

880035

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.279

Low

933199

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

1206600

PLAC9
Placenta-specific protein 9

1

0

High-throughput

0.279

Low

1277498

MON2
Protein MON2 homolog

1

0

High-throughput

0.279

Low

1324387

CNPY3
Protein canopy homolog 3

1

0

High-throughput

0.279

Low

1324396

B3GA2
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

1

0

High-throughput

0.279

Low

1324401

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

294004

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

377652

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

831056

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

1324139

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1324397

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1082

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

1324380

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025