Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF
Interactor 2: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.99 | 1.00 | 0.996 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28514442, 15173183, 11448951, 14743216, 30420664, 33961781, 2170559, 8288897, 8805640, 26186194, 25911380, 26670046, 27560715, 27307491, 27545878, 12887920, 31898971, 32968279, 33469115, 33815386 and 28 others
more... |
| Identification Methods | affinity chromatography technology, pull down, far western blotting, biochemical, tandem affinity purification, surface plasmon resonance, anti tag coimmunoprecipitation, solid phase assay, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | TNF~TNFR_c6 |
| Common GO terms | GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors and 11 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
