HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: NFAC3 (Q12968)
Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c)
Gene: NFATC3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16027109
Identification Methods	DNase I footprinting
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0043065 - positive regulation of apoptotic process GO:0045429 - positive regulation of nitric oxide biosynthetic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1902894 - negative regulation of miRNA transcription
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 1075
+	Mm
		78126 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		B5B2U4_MOUSE (1-1035): 0: 631: 89.96
+	Hs
		155683 TNF11_HUMAN (52-233): 5.98e-50: 167: 18.14		NFAC3_HUMAN (1-1075): 0: 712: 100.00
+	Hs
		352606 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NFAC2_HUMAN (43-864): 3.25e-91: 314: 34.15
+	Hs
		352617 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NFAC4_HUMAN (1-886): 3.64e-83: 291: 38.07
+	Mm
		420392 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		NFKB1_MOUSE (425-936): 2.25e-95: 327: 15.03
+	Hs
		352584 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		RELB_HUMAN (328-829): 4.73e-75: 261: 17.33
+	Hs
		317883 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NFAC1_HUMAN (30-823): 1.56e-71: 259: 39.81
+	Hs
		669879 CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49		REL_HUMAN (431-970): 1.12e-130: 412: 17.99
+	Hs
		352589 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		TF65_HUMAN (418-813): 4.46e-68: 240: 21.91
+	Mm
		420398 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		RELB_MOUSE (388-829): 8.24e-81: 276: 16.60
+	Hs
		300514 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NFAT5_HUMAN (318-883): 2.62e-60: 228: 28.77
+	Mm
		420397 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		TF65_MOUSE (418-829): 6.92e-66: 234: 20.14
+	Mm
		420412 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		NFAT5_MOUSE (318-888): 5.9e-59: 224: 28.22
+	Hs
		669883 CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49		NFAC2_HUMAN (43-864): 3.25e-91: 314: 34.15
+	Hs
		317913 CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49		NFAC1_HUMAN (30-823): 1.56e-71: 259: 39.81
+	Hs
		815717 TNFL6_HUMAN (20-233): 2.88e-72: 223: 25.46		MYO15_HUMAN (75-491): 7.31e-16: 85.6: 11.77