HitPredict

Interactor 1: H2B (P02283)
Histone H2B
Gene: H2B, His2B;

Interactor 2: H4 (P84040)
Histone H4
Gene: His4

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	27956707
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~Histone
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 123 Dm			1 103
+	Hs
		917818 H2B1M_HUMAN (3-123): 2.3e-49: 155: 80.49		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		617943 H2B1O_HUMAN (3-123): 3.29e-49: 154: 82.11		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		917397 H2B2F_HUMAN (3-123): 3.44e-49: 154: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		917700 H2B1H_HUMAN (3-123): 5.28e-49: 154: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		420818 H2B1J_HUMAN (3-123): 1.27e-48: 153: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		707573 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		883007 H2BFS_HUMAN (3-123): 1.72e-48: 153: 78.86		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		917062 H2B1C_HUMAN (3-123): 1.51e-48: 153: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		917355 H2B2E_HUMAN (3-123): 9.53e-49: 153: 82.11		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		241492 H2B1K_HUMAN (3-123): 2.12e-48: 152: 80.49		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		886073 H2B1D_HUMAN (3-123): 2.76e-48: 152: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		917816 H2B1N_HUMAN (3-123): 2.91e-48: 152: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Xl
		355249 H2B11_XENLA (3-123): 1.92e-47: 150: 80.49		H4_XENLA (1-103): 1.72e-48: 151: 99.03
+	Hs
		917819 H2B1L_HUMAN (4-123): 2.63e-47: 149: 81.15		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		917708 H2B1A_HUMAN (3-123): 2.12e-43: 139: 78.57		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		1087360 H2B2E_HUMAN (3-123): 9.53e-49: 153: 82.11		H4G_HUMAN (1-98): 1.39e-38: 126: 83.67
+	Hs
		241620 H2B1K_HUMAN (3-123): 2.12e-48: 152: 80.49		H4G_HUMAN (1-98): 1.39e-38: 126: 83.67
+	Hs
		886179 H2B1D_HUMAN (3-123): 2.76e-48: 152: 81.30		H4G_HUMAN (1-98): 1.39e-38: 126: 83.67
+	Hs
		1304370 H2B1L_HUMAN (4-123): 2.63e-47: 149: 81.15		H4G_HUMAN (1-98): 1.39e-38: 126: 83.67
+	Sc
		355713 H2B2_YEAST (3-122): 1.26e-41: 135: 68.33		H4_YEAST (18-103): 5.86e-41: 132: 90.70