HitPredict - High confidence protein-protein interactions

Interactor 1: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Interactor 2: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.993

Property	Details
Experiments	18330356, 25416956, 25449278, 25962097, 26458046, 28130664, 29520626, 10625651, 11700327, 32417755, 16480679, 12601044, 19140694, 17075130, 18941542, 20802487, 19646995, 22143763, 18639655, 26465331 and 6 others more... 19651604, 21464278, 22153508, 24183572, 27226619, 23188086
Identification Methods	two hybrid, affinity chromatography technology, x-ray crystallography, pull down, fluorescent resonance energy transfer, transmission electron microscopy, molecular sieving, cosedimentation in solution, dynamic light scattering, nuclear magnetic resonance and 6 others more... x ray scattering, cross-linking study, 3D electron microscopy, mass spectrometry studies of complexes, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Crystallin~Crystallin, Crystallin~HSP20, HSP20~HSP20
Common GO terms	GO:0001540 - amyloid-beta binding GO:0001666 - response to hypoxia GO:0002088 - lens development in camera-type eye GO:0005198 - structural molecule activity GO:0005212 - structural constituent of eye lens and 44 others more... GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005764 - lysosome GO:0005829 - cytosol GO:0006457 - protein folding GO:0006936 - muscle contraction GO:0007021 - tubulin complex assembly GO:0007517 - muscle organ development GO:0008017 - microtubule binding GO:0009408 - response to heat GO:0009986 - cell surface GO:0010629 - negative regulation of gene expression GO:0030018 - Z disc GO:0030308 - negative regulation of cell growth GO:0030424 - axon GO:0031109 - microtubule polymerization or depolymerization GO:0031333 - negative regulation of protein-containing complex assembly GO:0031430 - M band GO:0032355 - response to estradiol GO:0032387 - negative regulation of intracellular transport GO:0032432 - actin filament bundle GO:0032991 - protein-containing complex GO:0042026 - protein refolding GO:0042542 - response to hydrogen peroxide GO:0042803 - protein homodimerization activity GO:0043066 - negative regulation of apoptotic process GO:0043067 - regulation of programmed cell death GO:0043197 - dendritic spine GO:0043204 - perikaryon GO:0044877 - protein-containing complex binding GO:0045892 - negative regulation of DNA-templated transcription GO:0046872 - metal ion binding GO:0050821 - protein stabilization GO:0051082 - unfolded protein binding GO:0051403 - stress-activated MAPK cascade GO:0060561 - apoptotic process involved in morphogenesis GO:0070062 - extracellular exosome GO:0071480 - cellular response to gamma radiation GO:0097060 - synaptic membrane GO:0097512 - cardiac myofibril GO:1905907 - negative regulation of amyloid fibril formation GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1	175
Hs

1	175

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Last updated: 15 Jul 2024