HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: PCGF2 (P35227)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Gene: PCGF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	16248985
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 344
+	Hs
		359705 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		595115 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00
+	Hs
		717734 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		318779 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		282510 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		RNF8_HUMAN (2-101): 6.37e-23: 101: 25.00
+	Hs
		282457 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		RNF8_HUMAN (2-101): 6.37e-23: 101: 25.00
+	Hs
		282465 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		RNF8_HUMAN (2-101): 6.37e-23: 101: 25.00
+	Hs
		717925 K2C79_HUMAN (23-398): 7.55e-42: 161: 21.90		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		717890 K2C71_HUMAN (23-390): 2.92e-41: 159: 21.68		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		535335 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		569051 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		359651 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RO52_HUMAN (8-210): 4.32e-32: 127: 15.02
+	Hs
		360442 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI39_HUMAN (9-186): 2.19e-27: 114: 16.58
+	Hs
		282458 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RNF8_HUMAN (2-101): 6.37e-23: 101: 25.00
+	Hs
		975721 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		RING2_HUMAN (4-234): 2.68e-45: 159: 17.49
+	Hs
		584872 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		RO52_HUMAN (8-210): 4.32e-32: 127: 15.02
+	Hs
		443747 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		RING2_HUMAN (4-234): 2.68e-45: 159: 17.49
+	Hs
		443320 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		RO52_HUMAN (8-210): 4.32e-32: 127: 15.02
+	Hs
		443720 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		CHFR_HUMAN (8-150): 4.68e-28: 116: 17.93