Protein: DHE4
NADP-specific glutamate dehydrogenase 1 (NADP-GDH 1) (EC 1.4.1.4) (NADP-dependent glutamate dehydrogenase 1)

Gene: DHE4, GDH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 112
UniProt ID: P07262

Gene Ontology (top 5):
GO:0004354 - glutamate dehydrogenase (NADP+) activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006537 - glutamate biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

454106

DHE5
NADP-specific glutamate dehydrogenase 2

2

7

High-throughput

0.737

High

454052

DHE4
NADP-specific glutamate dehydrogenase 1

1

7

Small-scale

0.691

High

454116

LSM1
LSM1-LSM7 complex subunit LSM1

2

1

High-throughput

0.603

High

454053

PBS2
MAP kinase kinase PBS2

2

1

High-throughput

0.594

High

454078

SIS1
Protein SIS1

2

0

High-throughput

0.576

High

364870

KPYK1
Pyruvate kinase 1

2

1

High-throughput

0.571

High

454112

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

454115

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

454058

HSP71
Heat shock protein SSA1

2

4

High-throughput

0.552

High

454061

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.552

High

454089

HSP7F
Heat shock protein homolog SSE1

2

5

High-throughput

0.552

High

454102

RPN1
26S proteasome regulatory subunit RPN1

2

0

High-throughput

0.547

High

454098

YPT52
GTP-binding protein YPT52

1

2

High-throughput

0.536

High

454054

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.513

High

454091

RAEP
Rab proteins geranylgeranyltransferase component A

1

0

High-throughput

0.513

High

454117

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.513

High

454124

MCE1
mRNA-capping enzyme subunit alpha

1

0

High-throughput

0.513

High

454125

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

440995

KAPA
cAMP-dependent protein kinase type 1

1

1

High-throughput

0.500

High

454075

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.500

High

454079

RV161
Reduced viability upon starvation protein 161

1

3

High-throughput

0.500

High

454097

VPS21
Vacuolar protein sorting-associated protein 21

1

2

High-throughput

0.500

High

454107

RV167
Reduced viability upon starvation protein 167

1

4

High-throughput

0.500

High

454143

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.500

High

454067

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.479

High

454076

PP11
Serine/threonine-protein phosphatase PP1-1

1

0

High-throughput

0.479

High

454080

DMC1
Meiotic recombination protein DMC1

1

0

High-throughput

0.479

High

454081

GID7
GID complex subunit 7

1

0

High-throughput

0.479

High

454100

IMB2
Importin subunit beta-2

1

0

High-throughput

0.479

High

454121

SSK2
MAP kinase kinase kinase SSK2

1

0

High-throughput

0.479

High

358935

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.479

High

367648

ENO1
Enolase 1

1

1

High-throughput

0.479

High

367853

ENO2
Enolase 2

1

1

High-throughput

0.479

High

392016

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.479

High

439188

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.479

High

454056

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

Small-scale

0.479

High

454063

SRS2
ATP-dependent DNA helicase SRS2

1

1

High-throughput

0.479

High

454064

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

454070

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

454082

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

454084

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

454085

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.479

High

454086

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

454104

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

454105

DHH1
ATP-dependent RNA helicase DHH1

1

3

High-throughput

0.479

High

454123

HST2
NAD-dependent protein deacetylase HST2

1

3

High-throughput

0.479

High

454128

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

454131

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

454137

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.479

High

454140

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

361407

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

365523

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

368381

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

368546

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

416341

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

434697

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

441606

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

454062

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

454065

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

454069

TAL1
Transaldolase

1

0

High-throughput

0.458

High

454088

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

454090

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

454093

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

454096

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.458

High

454108

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.458

High

454114

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

454118

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

454127

COFI
Cofilin

1

0

High-throughput

0.458

High

454129

YD391
Uncharacterized protein YDR391C

1

0

High-throughput

0.458

High

454134

SGO1
Shugoshin

1

0

High-throughput

0.458

High

454141

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

454142

ENT1
Epsin-1

1

0

High-throughput

0.458

High

358084

ADH1
Alcohol dehydrogenase 1

1

1

High-throughput

0.445

High

394114

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

453349

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

454057

IF4A
ATP-dependent RNA helicase eIF4A

1

4

High-throughput

0.445

High

454059

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

454071

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

454087

EF2
Elongation factor 2

1

2

High-throughput

0.445

High

454094

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

454110

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

454113

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.445

High

454138

HSP42
Heat shock protein 42

1

1

High-throughput

0.445

High

454074

PDI
Protein disulfide-isomerase

1

1

High-throughput

0.437

High

454083

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

454099

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.437

High

454101

YB8A
Putative uncharacterized protein YBR285W

1

1

Small-scale

0.437

High

454135

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

454136

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.437

High

454139

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

386519

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

454055

TBA3
Tubulin alpha-3 chain

1

0

High-throughput

0.426

High

454060

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.426

High

454072

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.426

High

454077

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.426

High

454095

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.426

High

454109

IMB4
Importin subunit beta-4

1

0

High-throughput

0.426

High

454111

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.426

High

454126

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.417

High

454073

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.407

High

454103

TOM71
Protein TOM71

1

1

High-throughput

0.407

High

148850

CET1
mRNA-capping enzyme subunit beta

1

0

High-throughput

0.279

Low

454132

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

0

High-throughput

0.269

Low

454092

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

454120

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.261

Low

454122

COPA
Coatomer subunit alpha

1

0

High-throughput

0.261

Low

454130

UTP5
U3 small nucleolar RNA-associated protein 5

1

0

High-throughput

0.261

Low

454119

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

454133

ZEO1
Protein ZEO1

1

0

High-throughput

0.249

Low

454066

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.238

Low

454068

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025