Interactor 1: APOE (P02649)
Apolipoprotein E (Apo-E)
Gene: APOE

Interactor 2: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 0.60 0.595

The method score is based on:

Property Details
Experiments 11294867, 17326667
Identification Methods pull down, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001540 - amyloid-beta binding
GO:0005615 - extracellular space
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus
and 6 others

more...

Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 317
Hs

1 2214
+ Hs
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024