Protein: THRB
Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]

Gene: THRB, F2
Organism: Homo sapiens
Interactions: 49
UniProt ID: P00734

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0004252 - serine-type endopeptidase activity
GO:0005102 - signaling receptor binding
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366087

TRBM
Thrombomodulin

4

20

Small-scale

0.888

High

366072

FA10
Coagulation factor X

2

15

Small-scale

0.768

High

366074

ANT3
Antithrombin-III

2

20

Small-scale

0.768

High

366082

A4
Amyloid-beta precursor protein

1

20

High-throughput

0.665

High

366083

PAI1
Plasminogen activator inhibitor 1

1

20

Small-scale

0.647

High

366084

IPSP
Plasma serine protease inhibitor

1

20

Small-scale

0.647

High

366085

IC1
Plasma protease C1 inhibitor

1

20

Small-scale

0.647

High

366097

SPB6
Serpin B6

1

20

Small-scale

0.647

High

366108

CBPB2
Carboxypeptidase B2

1

4

Small-scale

0.647

High

366075

LDLR
Low-density lipoprotein receptor

1

11

High-throughput

0.618

High

366078

FIBG
Fibrinogen gamma chain

1

8

Small-scale

0.618

High

366095

1433T
14-3-3 protein theta

2

3

High-throughput

0.601

High

366073

TPA
Tissue-type plasminogen activator

1

15

Small-scale

0.575

High

366077

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

8

Small-scale

0.575

High

366086

HEP2
Heparin cofactor 2

1

20

Small-scale

0.575

High

194430

P2RX6
P2X purinoceptor 6

1

2

High-throughput

0.536

High

366080

ALBU
Albumin

1

4

High-throughput

0.536

High

366093

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

366096

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.536

High

366101

INHBE
Inhibin beta E chain

1

5

High-throughput

0.536

High

366098

DDIT3
DNA damage-inducible transcript 3 protein

1

0

High-throughput

0.518

High

361562

FA8
Coagulation factor VIII

1

12

Small-scale

0.501

High

366088

TSP1
Thrombospondin-1

1

15

Small-scale

0.501

High

366089

ITA2B
Integrin alpha-IIb

1

6

Small-scale

0.501

High

366090

TAU
Microtubule-associated protein tau

1

3

Small-scale

0.501

High

366091

FA5
Coagulation factor V

1

12

Small-scale

0.501

High

366094

PAR1
Proteinase-activated receptor 1

1

5

Small-scale

0.501

High

366100

F10A1
Hsc70-interacting protein

1

3

Small-scale

0.501

High

366105

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

6

High-throughput

0.489

High

366109

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

1

High-throughput

0.489

High

366110

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

3

High-throughput

0.489

High

366103

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.484

High

366076

APOC3
Apolipoprotein C-III

1

1

High-throughput

0.479

High

366079

FINC
Fibronectin

1

9

Small-scale

0.479

High

366081

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

366092

TIMP2
Metalloproteinase inhibitor 2

1

5

High-throughput

0.479

High

366104

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

366106

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

366111

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

366115

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

240432

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.437

High

277216

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

366102

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.437

High

366107

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

366112

TRI31
E3 ubiquitin-protein ligase TRIM31

1

5

High-throughput

0.437

High

366113

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.437

High

366114

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

366099

CAMP
Cathelicidin antimicrobial peptide

1

1

Small-scale

0.408

High

247589

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025