Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.78 | 1.00 | 0.884 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25402006, 24658140, 38496616, unassigned2173 |
| Identification Methods | two hybrid, protein complementation assay, proximity labelling technology, ubiquitin reconstruction |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Pkinase, PK_Tyr_Ser-Thr~RBD |
| Common GO terms | GO:0004709 - MAP kinase kinase kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus and 8 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
