HitPredict

Interactor 1: PLF4 (P02776)
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form (Endothelial cell growth inhibitor)]
Gene: PF4

Interactor 2: CXCR3 (P49682)
C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
Gene: CXCR3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12782716
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0005737 - cytoplasm GO:0006954 - inflammatory response GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0016525 - negative regulation of angiogenesis GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Hs			1 368
+	Hs
		625748 CXCL5_HUMAN (21-100): 1.55e-29: 103: 41.25		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		625736 CXCL5_HUMAN (21-100): 1.55e-29: 103: 41.25		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Hs
		364042 CXCL7_HUMAN (26-99): 4.02e-28: 100: 50.00		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		587767 CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		364041 CXCL7_HUMAN (26-99): 4.02e-28: 100: 50.00		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Hs
		448988 GROA_HUMAN (35-101): 1.01e-27: 99: 46.27		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		448987 GROA_HUMAN (35-101): 1.01e-27: 99: 46.27		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Hs
		625758 CXCL6_HUMAN (28-101): 7.85e-27: 96.6: 40.54		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		587786 CXCL3_HUMAN (35-100): 9.16e-27: 96.3: 40.91		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		625737 CXCL6_HUMAN (28-101): 7.85e-27: 96.6: 40.54		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Hs
		486185 IL8_HUMAN (26-100): 4.32e-25: 92: 31.58		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		486184 IL8_HUMAN (26-100): 4.32e-25: 92: 31.58		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Hs
		364107 CXL10_HUMAN (17-98): 1.58e-21: 82.8: 26.19		CCR3_HUMAN (43-336): 1.14e-80: 252: 33.45
+	Hs
		849615 CXCL9_HUMAN (31-97): 3.46e-21: 82.8: 27.94		CCR3_HUMAN (43-336): 1.14e-80: 252: 33.45
+	Hs
		364105 CXL10_HUMAN (17-98): 1.58e-21: 82.8: 26.19		CXCR3_HUMAN (1-368): 8.13e-79: 247: 100.00
+	Hs
		830623 CXCL9_HUMAN (31-97): 3.46e-21: 82.8: 27.94		CXCR3_HUMAN (1-368): 8.13e-79: 247: 100.00
+	Mm
		291525 CXCL9_MOUSE (14-97): 1.36e-25: 93.9: 27.06		CXCR3_MOUSE (1-368): 1.26e-72: 232: 86.41
+	Mm
		291524 CXL10_MOUSE (19-98): 5.49e-23: 86.6: 28.05		CXCR3_MOUSE (1-368): 1.26e-72: 232: 86.41
+	Mm
		500672 CXCL2_MOUSE (30-100): 2.89e-28: 100: 46.48		CXCR2_MOUSE (12-351): 3.11e-65: 212: 34.11
+	Mm
		522397 GROA_MOUSE (31-100): 1.96e-28: 100: 44.29		CXCR2_MOUSE (12-351): 3.11e-65: 212: 34.11