HitPredict

Interactor 1: PLF4 (P02776)
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form (Endothelial cell growth inhibitor)]
Gene: PF4

Interactor 2: CCL26 (Q9Y258)
C-C motif chemokine 26 (CC chemokine IMAC) (Eotaxin-3) (Macrophage inflammatory protein 4-alpha) (MIP-4-alpha) (Small-inducible cytokine A26) (Thymic stroma chemokine-1) (TSC-1)
Gene: CCL26

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.716

Property	Details
Experiments	28381538
Identification Methods	pull down, surface plasmon resonance, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0008009 - chemokine activity GO:0030593 - neutrophil chemotaxis GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Hs			1 94
+	Hs
		364089 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		CCL13_HUMAN (2-91): 2.05e-31: 107: 33.70
+	Hs
		364088 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		CCL17_HUMAN (1-89): 5.64e-28: 98.9: 29.21
+	Hs
		364074 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		CCL2_HUMAN (16-93): 9.59e-27: 95.8: 27.85
+	Hs
		364075 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		CCL5_HUMAN (14-90): 3.98e-25: 91.6: 37.66
+	Hs
		364081 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		CCL11_HUMAN (16-92): 6.19e-25: 91.2: 34.62
+	Hs
		179462 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		CCL25_HUMAN (4-94): 5.9e-24: 90: 27.84
+	Hs
		587776 CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67		CCL8_HUMAN (16-90): 1.05e-28: 100: 34.21
+	Hs
		791124 CXCL5_HUMAN (21-100): 1.55e-29: 103: 41.25		CCL11_HUMAN (16-92): 6.19e-25: 91.2: 34.62
+	Hs
		364093 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		XCL2_HUMAN (6-92): 2.14e-21: 82.7: 28.74
+	Hs
		364082 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		CCL20_HUMAN (1-93): 2.02e-21: 82.3: 25.26
+	Hs
		528237 CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67		CCL5_HUMAN (14-90): 3.98e-25: 91.6: 37.66
+	Hs
		364078 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		XCL1_HUMAN (6-92): 5.59e-21: 81.5: 29.89
+	Hs
		587775 CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67		CCL11_HUMAN (16-92): 6.19e-25: 91.2: 34.62
+	Hs
		791136 CXCL5_HUMAN (21-100): 1.55e-29: 103: 41.25		XCL2_HUMAN (6-92): 2.14e-21: 82.7: 28.74
+	Hs
		791125 CXCL5_HUMAN (21-100): 1.55e-29: 103: 41.25		CCL20_HUMAN (1-93): 2.02e-21: 82.3: 25.26
+	Hs
		587784 CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67		XCL2_HUMAN (6-92): 2.14e-21: 82.7: 28.74
+	Hs
		134284 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		CCL21_HUMAN (25-91): 5.26e-17: 71.9: 28.17
+	Hs
		587772 CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67		XCL1_HUMAN (6-92): 5.59e-21: 81.5: 29.89
+	Hs
		134283 CXCL7_HUMAN (26-99): 4.02e-28: 100: 50.00		CCL21_HUMAN (25-91): 5.26e-17: 71.9: 28.17
+	Hs
		134290 CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67		CCL21_HUMAN (25-91): 5.26e-17: 71.9: 28.17