HitPredict

Interactor 1: CXL10 (P02778)
C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]
Gene: CXCL10

Interactor 2: CXCR3 (P49682)
C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
Gene: CXCR3

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.814

The method score is based on:

Property Details
Experiments 12782716, 9625760, 9660793
Identification Methods pull down, experimental interaction detection, biochemical
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~IL8
Common GO terms GO:0006935 - chemotaxis
GO:0006954 - inflammatory response
GO:0007166 - cell surface receptor signaling pathway
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 98
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024